TY - JOUR
T1 - Pathology of fatty liver
T2 - differential diagnosis of non-alcoholic fatty liver disease
AU - Yeh, Matthew M.
AU - Brunt, Elizabeth M.
PY - 2008/12
Y1 - 2008/12
N2 - Non-alcoholic fatty liver disease (NAFLD) has emerged as a worldwide epidemic in the 21st century. The spectrum of its histopathology ranges from simple steatosis to steatohepatitis, with risk for progressive fibrosis that may lead to cirrhosis and hepatocellular carcinoma. This review is an update of the histopathology of NAFLD and its differential diagnosis, in particular alcoholic liver disease (ALD), encountered by practising pathologists. It also discusses the pathology of NAFLD in various 'non-traditional' settings: in children, after therapeutic intervention, and with concomitant liver diseases. The current grading and staging systems of NAFLD and ALD are also discussed.
AB - Non-alcoholic fatty liver disease (NAFLD) has emerged as a worldwide epidemic in the 21st century. The spectrum of its histopathology ranges from simple steatosis to steatohepatitis, with risk for progressive fibrosis that may lead to cirrhosis and hepatocellular carcinoma. This review is an update of the histopathology of NAFLD and its differential diagnosis, in particular alcoholic liver disease (ALD), encountered by practising pathologists. It also discusses the pathology of NAFLD in various 'non-traditional' settings: in children, after therapeutic intervention, and with concomitant liver diseases. The current grading and staging systems of NAFLD and ALD are also discussed.
KW - alcoholic liver disease
KW - fatty liver
KW - non-alcoholic
KW - steatohepatitis
UR - https://www.scopus.com/pages/publications/56249115241
U2 - 10.1016/j.mpdhp.2008.09.005
DO - 10.1016/j.mpdhp.2008.09.005
M3 - Article
AN - SCOPUS:56249115241
SN - 1756-2317
VL - 14
SP - 586
EP - 597
JO - Diagnostic Histopathology
JF - Diagnostic Histopathology
IS - 12
ER -