Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Keyphrases

• Induced Pluripotent Stem Cells (iPSCs) 100%
• Frontotemporal Dementia 100%
• Pathological Progression 100%
• Tau mutation 100%
• R406W 100%
• Patient-specific iPSCs 100%
• Tau Protein 66%
• Tau Pathology 33%
• Alzheimer's Disease 33%
• Disease Pathology 33%
• Cas9 Protein 33%
• Axon 33%
• Morphological Abnormalities 33%
• Calpain 33%
• Functional Abnormalities 33%
• Missense mutation 33%
• Cortical Neurons 33%
• Stem Cell Models 33%
• Phosphorylation State 33%
• High Purity 33%
• Microtubule Stability 33%
• Neuronal Culture 33%
• Cerebral Organoids 33%
• Isogenic Lines 33%
• Microtubule-associated Protein tau Gene 33%
• Alzheime's Disease 33%
• Mechanistic Insights 33%
• Therapeutic Interventions 33%
• Patient-derived 33%
• Established Patient 33%

Neuroscience

• Frontotemporal Dementia 100%
• Tau Protein 100%
• Alzheimer's Disease 33%
• Stem Cell 33%
• Microtubule 33%
• CRISPR 33%
• Missense Mutation 33%
• Calpain 33%
• Axon 33%
• Organoid 33%
• phosphorylation 33%

Biochemistry, Genetics and Molecular Biology

• Tau 100%
• Tau Protein 100%
• Induced Pluripotent Stem Cell 33%
• CRISPR/Cas9 33%
• Axon 33%
• Calpain 33%
• Morphology 33%
• Missense Mutation 33%
• Nerve Cell Culture 33%
• phosphorylation 33%