TY - JOUR
T1 - Pathological glial tau accumulations in neurodegenerative disease
T2 - Review and case report
AU - Berry, Robert W.
AU - Quinn, Bruce
AU - Johnson, Nancy
AU - Cochran, Elizabeth J.
AU - Ghoshal, Nupur
AU - Binder, Lester I.
N1 - Funding Information:
The authors wish to thank Alison Sweet for skilled technical assistance. We are grateful to Dr A. Delacourte and Dr L. Buee for sharing the AD2 antibody with us. This work was supported by NIH grants AG09465 and AG13854.
PY - 2001
Y1 - 2001
N2 - Abnormal deposits of tau protein accumulate in glia in many neurodegenerative diseases. This suggests that in some instances the disease process may target glial tau, with neuronal degeneration a secondary consequence of this process. In this report, we summarize the pattern of glial tau pathology in various neurodegenerative disorders and add original findings from a case of sporadic frontotemporal dementia that exhibits astrocytic tau pathology. The neurodegenerative diseases span the spectrum of relative neuronal and glial tau involvement, from disorders affecting only neuronal tau to those in which abnormal tau deposits are found only in glia. From this, we conclude that glial tau can be a primary target of the disease process, and that this can lead to neuronal degeneration.
AB - Abnormal deposits of tau protein accumulate in glia in many neurodegenerative diseases. This suggests that in some instances the disease process may target glial tau, with neuronal degeneration a secondary consequence of this process. In this report, we summarize the pattern of glial tau pathology in various neurodegenerative disorders and add original findings from a case of sporadic frontotemporal dementia that exhibits astrocytic tau pathology. The neurodegenerative diseases span the spectrum of relative neuronal and glial tau involvement, from disorders affecting only neuronal tau to those in which abnormal tau deposits are found only in glia. From this, we conclude that glial tau can be a primary target of the disease process, and that this can lead to neuronal degeneration.
UR - http://www.scopus.com/inward/record.url?scp=0034808141&partnerID=8YFLogxK
U2 - 10.1016/S0197-0186(01)00054-7
DO - 10.1016/S0197-0186(01)00054-7
M3 - Article
C2 - 11578782
AN - SCOPUS:0034808141
SN - 0197-0186
VL - 39
SP - 469
EP - 479
JO - Neurochemistry International
JF - Neurochemistry International
IS - 5-6
ER -