Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

John C. Morris, Joseph L. Price

Research output: Contribution to journalArticlepeer-review

414 Scopus citations

Abstract

The results of studies from the Washington University Alzheimer Disease (AD) Research Center and those from other centers and investigators regarding the neuropathologic correlates of normal aging and early-stage AD are reviewed. We conclude that widespread amyloid plaques in the neocortex best distinguishes very early stage AD, including "MCI" stage, and preclinical stages, from healthy brain aging. Other AD lesions, including increased formation of neurofibrillary tangles and neuronal degeneration appear to result from the amyloid-initiated pathologic process, although they may have a more immediate effect on expression and severity of dementia. These data provide strong support for anti-amyloid intervention as a preventive therapy for AD. It is now critical to develop methods to detect preclinical AD during life.

Original languageEnglish
Pages (from-to)101-118
Number of pages18
JournalJournal of Molecular Neuroscience
Volume17
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid plaques
  • Mild cognitive impairment

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