@article{39b4f7a6d9774c1faf4f955e714750cb,
title = "Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome",
abstract = "Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.",
author = "Handley, {Scott A.} and Thackray, {Larissa B.} and Guoyan Zhao and Rachel Presti and Miller, {Andrew D.} and Lindsay Droit and Peter Abbink and Maxfield, {Lori F.} and Amal Kambal and Erning Duan and Kelly Stanley and Joshua Kramer and MacRi, {Sheila C.} and Permar, {Sallie R.} and Schmitz, {Joern E.} and Keith Mansfield and Brenchley, {Jason M.} and Veazey, {Ronald S.} and Stappenbeck, {Thaddeus S.} and David Wang and Barouch, {Dan H.} and Virgin, {Herbert W.}",
note = "Funding Information: This work was supported by Project 10 of U54 AI057160-08 to D.W. for development of VirusHunter software, was initially funded by the National Center for Research Resources 1R01 RR032309, and is currently supported by the Office of Research Infrastructure Programs OD11170-02 to H.W.V. and D.H.B.; Crohn's and Colitis Foundation Grant 3132 to H.W.V. and T.S.S.; grants AI066305, AI066924, AI078526, and AI095985 to D.H.B.; AI65335 to J.E.S.; and grant 8P51OD011103-5 to A.D.M. and J.K. We would like to thank Angela Carville, Elizabeth Curran, and Vanessa Hirsch for assistance with these experiments. ",
year = "2012",
month = oct,
day = "12",
doi = "10.1016/j.cell.2012.09.024",
language = "English",
volume = "151",
pages = "253--266",
journal = "Cell",
issn = "0092-8674",
number = "2",
}