Pathogenic Germline Variants in 10,389 Adult Cancers

Keyphrases

• Adult Cancer 100%
• Biallelic 50%
• Breast Cancer Susceptibility Gene 1 (BRCA1) 50%
• Cancer Association 50%
• Cancer Types 50%
• Colocalization 50%
• Control Frequency 50%
• Expression Effects 50%
• Frequency Loss 50%
• Functional Consequences 50%
• Gene Expression 100%
• Germline Genetic Testing 50%
• Germline Variants 50%
• In Cancer 100%
• Integrative Approach 50%
• Large Deletion 50%
• Likely Pathogenic Variant 50%
• Loss of Heterozygosity 100%
• Melanoma 50%
• Oncogene 50%
• PALB2 50%
• Pan-cancer Analysis 50%
• Pathogenic Germline Variant 100%
• PTPN11 50%
• Stomach Adenocarcinoma 50%
• Tumor Suppressor 50%
• Two-hit 50%
• Variant Classification 50%

Biochemistry, Genetics and Molecular Biology

• BRCA1 33%
• Gene Expression 66%
• Genetic Screening 33%
• Germ Cell 100%
• Germline 100%
• Loss of Heterozygosity 66%
• Oncogene 33%
• PALB2 33%
• PTPN11 33%
• SDHA 33%
• Tumor Suppressor Protein 33%