Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice

Michelle M. Durkin, Patricia A. Connolly, Kian Karimi, Emerson Wheat, Carol Schnizlein-Bick, Stephen D. Alien, Katia Alves, Ram P. Tewari, Elizabeth Keath

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.

Original languageEnglish
Pages (from-to)4370-4373
Number of pages4
JournalJournal of clinical microbiology
Volume42
Issue number9
DOIs
StatePublished - Sep 2004

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