Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice

Michelle M. Durkin; Patricia A. Connolly; Kian Karimi; Emerson Wheat; Carol Schnizlein-Bick; Stephen D. Alien; Katia Alves; Ram P. Tewari; Elizabeth Keath

doi:10.1128/JCM.42.9.4370-4373.2004

Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice

Michelle M. Durkin, Patricia A. Connolly, Kian Karimi, Emerson Wheat, Carol Schnizlein-Bick, Stephen D. Alien, Katia Alves, Ram P. Tewari, Elizabeth Keath

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.

Original language	English
Pages (from-to)	4370-4373
Number of pages	4
Journal	Journal of clinical microbiology
Volume	42
Issue number	9
DOIs	https://doi.org/10.1128/JCM.42.9.4370-4373.2004
State	Published - Sep 2004

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Durkin, M. M., Connolly, P. A., Karimi, K., Wheat, E., Schnizlein-Bick, C., Alien, S. D., Alves, K., Tewari, R. P., & Keath, E. (2004). Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice. Journal of clinical microbiology, 42(9), 4370-4373. https://doi.org/10.1128/JCM.42.9.4370-4373.2004

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abstract = "Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.",

author = "Durkin, {Michelle M.} and Connolly, {Patricia A.} and Kian Karimi and Emerson Wheat and Carol Schnizlein-Bick and Alien, {Stephen D.} and Katia Alves and Tewari, {Ram P.} and Elizabeth Keath",

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Durkin, MM, Connolly, PA, Karimi, K, Wheat, E, Schnizlein-Bick, C, Alien, SD, Alves, K, Tewari, RP & Keath, E 2004, 'Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice', Journal of clinical microbiology, vol. 42, no. 9, pp. 4370-4373. https://doi.org/10.1128/JCM.42.9.4370-4373.2004

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AU - Durkin, Michelle M.

AU - Connolly, Patricia A.

AU - Karimi, Kian

AU - Wheat, Emerson

AU - Schnizlein-Bick, Carol

AU - Alien, Stephen D.

AU - Alves, Katia

AU - Tewari, Ram P.

AU - Keath, Elizabeth

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AB - Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.

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SN - 0095-1137

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Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice

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