TY - JOUR
T1 - Pathogenic Acinetobacter
T2 - From the cell surface to infinity and beyond
AU - Weber, Brent S.
AU - Harding, Christian M.
AU - Feldman, Mario F.
N1 - Funding Information:
Washington University School of Medicine provided funding to Brent S. Weber, Christian M. Harding, and Mario F. Feldman. Gouvernement du Canada/Natural Sciences and Engineering Research Council of Canada (NSERC) provided funding to Brent S. Weber. M.F.F. is a Washington University School of Medicine Faculty Diversity Scholar. B.S.W. is a recipient of the NSERC Postgraduate Scholarship-Doctoral award.
Publisher Copyright:
© 2016, American Society for Microbiology. All Rights Reserved.
PY - 2016
Y1 - 2016
N2 - The genus Acinetobacter encompasses multiple nosocomial opportunistic pathogens that are of increasing worldwide relevance because of their ability to survive exposure to various antimicrobial and sterilization agents. Among these, Acinetobacter baumannii, Acinetobacter nosocomialis, and Acinetobacter pittii are the most frequently isolated in hospitals around the world. Despite the growing incidence of multidrug-resistant Acinetobacter spp., little is known about the factors that contribute to pathogenesis. New strategies for treating and managing infections caused by multidrug-resistant Acinetobacter strains are urgently needed, and this requires a detailed understanding of the pathobiology of these organisms. In recent years, some virulence factors important for Acinetobacter colonization have started to emerge. In this review, we focus on several recently described virulence factors that act at the bacterial surface level, such as the capsule, O-linked protein glycosylation, and adhesins. Furthermore, we describe the current knowledge regarding the type II and type VI secretion systems present in these strains.
AB - The genus Acinetobacter encompasses multiple nosocomial opportunistic pathogens that are of increasing worldwide relevance because of their ability to survive exposure to various antimicrobial and sterilization agents. Among these, Acinetobacter baumannii, Acinetobacter nosocomialis, and Acinetobacter pittii are the most frequently isolated in hospitals around the world. Despite the growing incidence of multidrug-resistant Acinetobacter spp., little is known about the factors that contribute to pathogenesis. New strategies for treating and managing infections caused by multidrug-resistant Acinetobacter strains are urgently needed, and this requires a detailed understanding of the pathobiology of these organisms. In recent years, some virulence factors important for Acinetobacter colonization have started to emerge. In this review, we focus on several recently described virulence factors that act at the bacterial surface level, such as the capsule, O-linked protein glycosylation, and adhesins. Furthermore, we describe the current knowledge regarding the type II and type VI secretion systems present in these strains.
UR - http://www.scopus.com/inward/record.url?scp=84960409046&partnerID=8YFLogxK
U2 - 10.1128/JB.00906-15
DO - 10.1128/JB.00906-15
M3 - Article
C2 - 26712938
AN - SCOPUS:84960409046
VL - 198
SP - 880
EP - 887
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 6
ER -