TY - JOUR
T1 - Pathogenesis of necrotizing enterocolitis
T2 - Modeling the innate immune response
AU - Tanner, Scott M.
AU - Berryhill, Taylor F.
AU - Ellenburg, James L.
AU - Jilling, Tamas
AU - Cleveland, Dava S.
AU - Lorenz, Robin G.
AU - Martin, Colin A.
N1 - Publisher Copyright:
© 2015 American Society for Investigative Pathology Published by Elsevier Inc. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. The pathophysiology is likely secondary to innate immune responses to intestinal microbiota by the premature infant's intestinal tract, leading to inflammation and injury. This review provides an updated summary of the components of the innate immune system involved in NEC pathogenesis. In addition, we evaluate the animal models that have been used to study NEC with regard to the involvement of innate immune factors and histopathological changes as compared to those seen in infants with NEC. Finally, we discuss new approaches to studying NEC, including mathematical models of intestinal injury and the use of humanized mice.
AB - Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. The pathophysiology is likely secondary to innate immune responses to intestinal microbiota by the premature infant's intestinal tract, leading to inflammation and injury. This review provides an updated summary of the components of the innate immune system involved in NEC pathogenesis. In addition, we evaluate the animal models that have been used to study NEC with regard to the involvement of innate immune factors and histopathological changes as compared to those seen in infants with NEC. Finally, we discuss new approaches to studying NEC, including mathematical models of intestinal injury and the use of humanized mice.
UR - http://www.scopus.com/inward/record.url?scp=84918785790&partnerID=8YFLogxK
U2 - 10.1016/j.ajpath.2014.08.028
DO - 10.1016/j.ajpath.2014.08.028
M3 - Review article
C2 - 25447054
AN - SCOPUS:84918785790
SN - 0002-9440
VL - 185
SP - 4
EP - 16
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 1
ER -