TY - JOUR
T1 - Pathogenesis of HIV in the central nervous system
AU - Valcour, Victor
AU - Sithinamsuwan, Pasiri
AU - Letendre, Scott
AU - Ances, Beau
PY - 2011/3
Y1 - 2011/3
N2 - HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of factors including inadequate treatment of HIV reservoirs such as circulating monocytes and glia, decreased effectiveness of cART in CNS, concurrent illnesses, stimulant use, and factors associated with prescribed drugs, including antiretrovirals. This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings.
AB - HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complications. HIV-associated neurocognitive disorders (HAND) remain common despite cART, although attenuated in severity. This may result from a combination of factors including inadequate treatment of HIV reservoirs such as circulating monocytes and glia, decreased effectiveness of cART in CNS, concurrent illnesses, stimulant use, and factors associated with prescribed drugs, including antiretrovirals. This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings.
KW - AIDS dementia complex
KW - Aging
KW - Cerebrospinal fluid
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=79952702553&partnerID=8YFLogxK
U2 - 10.1007/s11904-010-0070-4
DO - 10.1007/s11904-010-0070-4
M3 - Review article
C2 - 21191673
AN - SCOPUS:79952702553
SN - 1548-3568
VL - 8
SP - 54
EP - 61
JO - Current HIV/AIDS Reports
JF - Current HIV/AIDS Reports
IS - 1
ER -