The pathogenesis of human T-cell leukemia virus (HTLV)-induced adult T-cell leukemia-lymphoma (ATLL) was explored using an infectious molecular viral clone and a transgenic mouse model. Activation of nuclear factor-κB by the HTLV transcriptional trans-activator protein Tax was found to be important for lymphocyte immortalization and tumorigenesis. Interferon-γ regulates tumor development owing primarily to angiostatic effects. Translational clinical studies of chemotherapy, interferon-α, and nucleoside reverse transcriptase inhibitors have also assisted in identifying the pathogenic features of ATLL.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalImmunologic Research
Issue number1-3
StatePublished - 2005


  • Adult T-cell leukemia-lymphoma
  • Human T-cell leukemia virus
  • Immortalization
  • Interferon-γ
  • Lymphocytes
  • Tax


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