Abstract
The pathogenesis of human T-cell leukemia virus (HTLV)-induced adult T-cell leukemia-lymphoma (ATLL) was explored using an infectious molecular viral clone and a transgenic mouse model. Activation of nuclear factor-κB by the HTLV transcriptional trans-activator protein Tax was found to be important for lymphocyte immortalization and tumorigenesis. Interferon-γ regulates tumor development owing primarily to angiostatic effects. Translational clinical studies of chemotherapy, interferon-α, and nucleoside reverse transcriptase inhibitors have also assisted in identifying the pathogenic features of ATLL.
Original language | English |
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Pages (from-to) | 217-223 |
Number of pages | 7 |
Journal | Immunologic Research |
Volume | 32 |
Issue number | 1-3 |
DOIs | |
State | Published - 2005 |
Keywords
- Adult T-cell leukemia-lymphoma
- Human T-cell leukemia virus
- Immortalization
- Interferon-γ
- Lymphocytes
- Tax