TY - JOUR
T1 - Past use of oral contraceptives and cardiovascular disease
T2 - A meta-analysis in the context of the Nurses' Health Study
AU - Stampfer, Meir J.
AU - Willett, Walter C.
AU - Colditz, Graham A.
AU - Speizer, Frank E.
AU - Hennekens, Charles H.
N1 - Funding Information:
From the Channing Laboratory, Departments of Medicine" and Preventive Medicine/ Harvard Medical School and Brigham and Women's Hospital and the Departments of Epidemiolog/ and Nutrition,' Harvard School of Public Health. Supported by research grants HL 34594 and CA 40935 from the National Institutes of Health. Reprint requests: MeirJ. Stampfer. MD, Channing Laboratory, 180 Longwood Ave., Boston, MA 02115.
PY - 1990/7
Y1 - 1990/7
N2 - We examined the effects of past use of oral contraceptives on risks of cardiovascular diseases prospectively in the Nurses' Health Study cohort. The 119,061 participants were 30 to 55 years old and free of coronary disease or stroke in 1976. They provided information on biennial questionnaires and were followed for 8 years. There were 380 nonfatal myocardial infarctions and 105 deaths from coronary disease, 282 strokes, and 48 other cardiovascular deaths. We observed virtually no differences in the rates of various cardiovascular diseases between never and past users of oral contraceptives, regardless of duration of use or time since last use. For major coronary disease, the relative risk was 0.8 (95% confidence intervals, 0.6 to 1.0). A quantitative meta-analysis of 13 studies yielded an estimated relative risk of 1.01 (95% confidence intervals, 0.91 to 1.13) for coronary heart disease. Past use of oral contraceptives has little or no impact on risks of subsequent cardiovascular diseases.
AB - We examined the effects of past use of oral contraceptives on risks of cardiovascular diseases prospectively in the Nurses' Health Study cohort. The 119,061 participants were 30 to 55 years old and free of coronary disease or stroke in 1976. They provided information on biennial questionnaires and were followed for 8 years. There were 380 nonfatal myocardial infarctions and 105 deaths from coronary disease, 282 strokes, and 48 other cardiovascular deaths. We observed virtually no differences in the rates of various cardiovascular diseases between never and past users of oral contraceptives, regardless of duration of use or time since last use. For major coronary disease, the relative risk was 0.8 (95% confidence intervals, 0.6 to 1.0). A quantitative meta-analysis of 13 studies yielded an estimated relative risk of 1.01 (95% confidence intervals, 0.91 to 1.13) for coronary heart disease. Past use of oral contraceptives has little or no impact on risks of subsequent cardiovascular diseases.
KW - Oral contraceptives
KW - cardiovascular disease
KW - myocardial infarction
KW - stroke
KW - women
UR - http://www.scopus.com/inward/record.url?scp=0025181231&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(90)90569-S
DO - 10.1016/0002-9378(90)90569-S
M3 - Article
C2 - 2142573
AN - SCOPUS:0025181231
SN - 0002-9378
VL - 163
SP - 285
EP - 291
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 1 PART 2
ER -