Partitioning the heart: Mechanisms of cardiac septation and valve development

Chien Jung Lin, Chieh Yu Lin, Chen Hao Chen, Bin Zhou, Ching Pin Chang

Research output: Contribution to journalReview articlepeer-review

161 Scopus citations


Heart malformations are common congenital defects in humans. Many congenital heart defects involve anomalies in cardiac septation or valve development, and understanding the developmental mechanisms that underlie the formation of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart.

Original languageEnglish
Pages (from-to)3277-3299
Number of pages23
JournalDevelopment (Cambridge)
Issue number18
StatePublished - Sep 15 2012


  • Cardiac septation
  • Congenital heart disease
  • Heart development
  • Signaling
  • Transcription
  • Valve development


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