TY - JOUR
T1 - Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors
AU - Wilson, Thomas E.
AU - Paulsen, Ragnhild E.
AU - Padgett, Kerstien A.
AU - Milbrandt, Jeffrey
PY - 1992
Y1 - 1992
N2 - Steroid-thyroid hormone receptors typically bind as dinners to DNA sequences that contain repeated elements termed half-sites. NGFI-B, an early response protein and orphan member of this receptor superfamily, binds to a DNA sequence that contains only one half-site (5′-AAAGGTCA-3′). A domain separate from the NGFI-B zinc fingers, termed the A box, was identified and is required for recognition of the two adenine-thymidine (A-T) base pairs at the 5′ end of the NGFI-B DNA binding element. In addition, a domain downstream of the zinc fingers of the orphan receptor H-2 region II binding protein, termed the T box, determined binding to tandem repeats of the estrogen receptor half-site (5′-AGGTCA-3′).
AB - Steroid-thyroid hormone receptors typically bind as dinners to DNA sequences that contain repeated elements termed half-sites. NGFI-B, an early response protein and orphan member of this receptor superfamily, binds to a DNA sequence that contains only one half-site (5′-AAAGGTCA-3′). A domain separate from the NGFI-B zinc fingers, termed the A box, was identified and is required for recognition of the two adenine-thymidine (A-T) base pairs at the 5′ end of the NGFI-B DNA binding element. In addition, a domain downstream of the zinc fingers of the orphan receptor H-2 region II binding protein, termed the T box, determined binding to tandem repeats of the estrogen receptor half-site (5′-AGGTCA-3′).
UR - http://www.scopus.com/inward/record.url?scp=0026560372&partnerID=8YFLogxK
U2 - 10.1126/science.1314418
DO - 10.1126/science.1314418
M3 - Article
C2 - 1314418
AN - SCOPUS:0026560372
SN - 0036-8075
VL - 256
SP - 107
EP - 110
JO - Science
JF - Science
IS - 5053
ER -