Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity

Luzviminda V. Tinao-Wooldridge, Bonnie C.H. Hsiang, Tammy N. Latifi, James A. Ferrendelli, Douglas F. Covey

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

4,7,7-Trimethyl-6,8-dioxabicyclo[3.2.1]octan-2-one was found to be an effective anticonvulsant (ED50 = 131 mg/kg) against pentylenetetrazole-induced seizures in mice. Enantioselectively was observed in the actions of the (+)- and (-)-enantiomers as anticonvulsants and as displacers of [35S]-TPBS, a ligand for the picrotoxin site on GABAA receptors. The (-)-enantiomer was slightly more potent in both biological assays.

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number3
DOIs
StatePublished - Feb 2 1995

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