TY - JOUR
T1 - Partial adaptation to the value range in the macaque orbitofrontal cortex
AU - Conen, Katherine E.
AU - Padoa-Schioppa, Camillo
N1 - Funding Information:
Received Sept. 4, 2018; revised Jan. 21, 2019; accepted Feb. 13, 2019. Authorcontributions:K.E.C.andC.P.-S.designedresearch;K.E.C.performedresearch;K.E.C.analyzeddata;K.E.C. wrote the paper; C.P.-S. edited the paper. This work was supported by the National Institutes of Health (Grants R01-MH104494 to C.P.-S. and F31-MH107111 to K.E.C.). We thank H. Schoknecht for help with animal training and S. Ballesta, W. Shi, and E. Bromberg-Martin for comments on earlier versions of the paper. The authors declare no competing financial interests. Correspondence should be addressed to Camillo Padoa-Schioppa at camillo@wustl.edu. K. E. Conen’s present address: Department of Collective Behaviour, Max Planck Institute for Ornithology, and Department of Biology, University of Konstanz, Universitätsstraße 10, 78464 Konstanz, Germany. https://doi.org/10.1523/JNEUROSCI.2279-18.2019 Copyright © 2019 the authors
Funding Information:
This work was supported by the National Institutes of Health (Grants R01-MH104494 to C.P.-S. and F31- MH107111 to K.E.C.). We thank H. Schoknecht for help with animal training and S. Ballesta, W. Shi, and E. Bromberg-Martin for comments on earlier versions of the paper. The authors declare no competing financial interests.
Publisher Copyright:
© 2019 the authors.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Values available for choice in different behavioral contexts can vary immensely. To compensate for this variability, neuronal circuits underlying economic decisions undergo adaptation. In orbitofrontal cortex (OFC), neurons encode the subjective value of offered and chosen goods in a quasilinear way. Previous experiments found that the gain of the encoding is lower when the value range is wider. However, the parameters OFC neurons adapted to remained unclear. Furthermore, previous studies did not examine additive changes in neuronal responses. Computational considerations indicate that these factors can directly impact choice behavior. Here we investigated how OFC neurons adapt to changes in the value range. We recorded from two male rhesus monkeys during a juice choice task. Each session was divided into two blocks of trials. In each block, juices were offered within a set range of values, and ranges changed between blocks. Across blocks, neuronal responses adapted to both the maximum and the minimum value, but only partially. As a result, the minimum neural activity was elevated in some value ranges relative to others. Through simulation of a linear decision model, we showed that increasing the minimum response increases choice variability, lowering the expected payoff. This effect is modulated by the balance between cells with positive and negative encoding. The presence of these two populations induces a non-monotonic relationship between the value range and choice efficacy, such that the expected payoff is highest for decisions in an intermediate value range.
AB - Values available for choice in different behavioral contexts can vary immensely. To compensate for this variability, neuronal circuits underlying economic decisions undergo adaptation. In orbitofrontal cortex (OFC), neurons encode the subjective value of offered and chosen goods in a quasilinear way. Previous experiments found that the gain of the encoding is lower when the value range is wider. However, the parameters OFC neurons adapted to remained unclear. Furthermore, previous studies did not examine additive changes in neuronal responses. Computational considerations indicate that these factors can directly impact choice behavior. Here we investigated how OFC neurons adapt to changes in the value range. We recorded from two male rhesus monkeys during a juice choice task. Each session was divided into two blocks of trials. In each block, juices were offered within a set range of values, and ranges changed between blocks. Across blocks, neuronal responses adapted to both the maximum and the minimum value, but only partially. As a result, the minimum neural activity was elevated in some value ranges relative to others. Through simulation of a linear decision model, we showed that increasing the minimum response increases choice variability, lowering the expected payoff. This effect is modulated by the balance between cells with positive and negative encoding. The presence of these two populations induces a non-monotonic relationship between the value range and choice efficacy, such that the expected payoff is highest for decisions in an intermediate value range.
KW - Decision-making
KW - Economic choice
KW - Neuronal plasticity
KW - Optimal coding
KW - Range adaptation
KW - Subjective value
UR - http://www.scopus.com/inward/record.url?scp=85065543307&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.2279-18.2019
DO - 10.1523/JNEUROSCI.2279-18.2019
M3 - Article
C2 - 30833513
AN - SCOPUS:85065543307
SN - 0270-6474
VL - 39
SP - 3498
EP - 3513
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 18
ER -