PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2

PARIS/SPARTA Study Group

doi:10.1128/msphere.00179-22

PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2

PARIS/SPARTA Study Group

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARSCoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

Original language	English
Journal	mSphere
Volume	7
Issue number	3
DOIs	https://doi.org/10.1128/msphere.00179-22
State	Published - Jun 2022

Keywords

COVID-19
SARS-CoV-2
antibodies
cohort study
reinfection

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10.1128/msphere.00179-22

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@article{4afe516ca48c4e5b9e1c02794c6f287e,

title = "PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2",

abstract = "To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARSCoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.",

keywords = "COVID-19, SARS-CoV-2, antibodies, cohort study, reinfection",

author = "{PARIS/SPARTA Study Group} and Viviana Simon and Vamsi Kota and Bloomquist, {Ryan F.} and Hanley, {Hannah B.} and David Forgacs and Savita Pahwa and Suresh Pallikkuth and Miller, {Loren G.} and Joanna Schaenman and Yeaman, {Michael R.} and David Manthei and Joshua Wolf and Gaur, {Aditya H.} and Estepp, {Jeremie H.} and Komal Srivastava and Carre{\~n}o, {Juan Manuel} and Frans Cuevas and Ellebedy, {Ali H.} and Aubree Gordon and Riccardo Valdez and Sarah Cobey and Reed, {Elaine F.} and Ravindra Kolhe and Thomas, {Paul G.} and Stacey Schultz-Cherry and Ross, {Ted M.} and Florian Krammer and Klebert, {Michael K.} and {Turner Wooseob}, {Jackson S.} and Kalaidina, {Kim Elizaveta} and Presti, {Rachel M.} and O'Halloran, {Jane A.} and Alem Haile and Goss, {Charles W.} and Rauseo, {Adriana M.} and Aaron Schmitz and Tingting Lei and Erin Williams and Michael Hoffer and Hala Alshammary and Amoako, {Angela A.} and Dalles Andre and Awawda, {Mahmoud H.} and Katherine Beach and Carolina Berm{\'u}dez-Gonz{\'a}lez and Dominika Bielak and Cai, {Gianna Y.} and Ilaria Ceglia and Christian Cognigni and Charles Gleason and Hisaaki Kawabata and Giulio Kleiner and Neko Lyttle and Wanni Mendez and Mulder, {Lubbertus C.F.} and Annika Oostenink and Jose Polanco and Ariel Raskin and Aria Rooker and Ashley Salimbangon and Miti Saksena and Gagandeep Singh and Levy Sominsky and Johnstone Tcheou and Theresa Kowalski-Dobson and Carmen Gherasim and Emily Stoneman and Yoshihiro Kawaoka and Peter Halfman and Kevin Bakker and Victoria Blanc and Savanna Sneeringer and Joe Paulauskis and Jamie Bird and Lauren Warsinske and Mahboob Chowdhury and Dawson Davis and Alyssa Meyers and Kathleen Lindsey and Rebecca Tutino and Brittany Baker and Charlotte Bolle and Debbie Bratt and Courtney Briggs and Lillian Buescher and Jasmine Burris and Jordan Byrne and Michael Carlock and Patrick Fagan and Jasper Gattiker and Naveen Gokanapudi and Omar Hamwy and Tejal Hill and Lauren Howland and Hana Ji and Katie Mailloux and Brad Phillips and Kimberly Schmitz and Hua Shi and Cleopatria Smith and Terrie Waits and Emma Whitesell and Allen, {E. Kaitlynn} and Kim Allison and Hana Hakim and Hayden, {Randall T.} and Hijano, {Diego R.} and James Hoffman and McGargill, {Maureen A.} and Tomi Mori and Li Tang and Elaine Tuomanen and Richard Webby and Resha Bajracharya and Sean Cherry and Clark, {Brandi L.} and Dallas, {Ronald H.} and Thomas Fabrizio and Jason Hodges and Ashleigh Gowen and Lin, {Chun Yang} and Jamie Russell-Bell and James Sparks and Wittman, {David E.} and {Van de Velde}, {Lee Ann} and Wilson, {Taylor L.} and Roubidoux, {Ericka Kirkpatrick} and Valerie Cortez and Pamela Freiden and Nicholas Wohlgemuth and Kendall Whitt and Jaspreet Farmaha and James, {Jeffrey N.} and Carlock, {Caroline Marie} and Drew Fransoso and Ashis Mondal and Nikhil Sahajpal and Lara Churchwell and Kimya Jones and Sudha Ananth and Colin Williams and Reeya Patel and Patty Ray and Bradshaw Danielle and Justin Moore and Evelyn Flores and Deborah Kupferwasser and Prudencio Merino and Tran, {Donna Phan} and Jenkins, {Meagan M.} and Qifang Bi",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Simon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",

year = "2022",

month = jun,

doi = "10.1128/msphere.00179-22",

language = "English",

volume = "7",

journal = "mSphere",

issn = "2379-5042",

number = "3",

}

TY - JOUR

T1 - PARIS and SPARTA

T2 - Finding the Achilles' Heel of SARS-CoV-2

AU - PARIS/SPARTA Study Group

AU - Simon, Viviana

AU - Kota, Vamsi

AU - Bloomquist, Ryan F.

AU - Hanley, Hannah B.

AU - Forgacs, David

AU - Pahwa, Savita

AU - Pallikkuth, Suresh

AU - Miller, Loren G.

AU - Schaenman, Joanna

AU - Yeaman, Michael R.

AU - Manthei, David

AU - Wolf, Joshua

AU - Gaur, Aditya H.

AU - Estepp, Jeremie H.

AU - Srivastava, Komal

AU - Carreño, Juan Manuel

AU - Cuevas, Frans

AU - Ellebedy, Ali H.

AU - Gordon, Aubree

AU - Valdez, Riccardo

AU - Cobey, Sarah

AU - Reed, Elaine F.

AU - Kolhe, Ravindra

AU - Thomas, Paul G.

AU - Schultz-Cherry, Stacey

AU - Ross, Ted M.

AU - Krammer, Florian

AU - Klebert, Michael K.

AU - Turner Wooseob, Jackson S.

AU - Kalaidina, Kim Elizaveta

AU - Presti, Rachel M.

AU - O'Halloran, Jane A.

AU - Haile, Alem

AU - Goss, Charles W.

AU - Rauseo, Adriana M.

AU - Schmitz, Aaron

AU - Lei, Tingting

AU - Williams, Erin

AU - Hoffer, Michael

AU - Alshammary, Hala

AU - Amoako, Angela A.

AU - Andre, Dalles

AU - Awawda, Mahmoud H.

AU - Beach, Katherine

AU - Bermúdez-González, Carolina

AU - Bielak, Dominika

AU - Cai, Gianna Y.

AU - Ceglia, Ilaria

AU - Cognigni, Christian

AU - Gleason, Charles

AU - Kawabata, Hisaaki

AU - Kleiner, Giulio

AU - Lyttle, Neko

AU - Mendez, Wanni

AU - Mulder, Lubbertus C.F.

AU - Oostenink, Annika

AU - Polanco, Jose

AU - Raskin, Ariel

AU - Rooker, Aria

AU - Salimbangon, Ashley

AU - Saksena, Miti

AU - Singh, Gagandeep

AU - Sominsky, Levy

AU - Tcheou, Johnstone

AU - Kowalski-Dobson, Theresa

AU - Gherasim, Carmen

AU - Stoneman, Emily

AU - Kawaoka, Yoshihiro

AU - Halfman, Peter

AU - Bakker, Kevin

AU - Blanc, Victoria

AU - Sneeringer, Savanna

AU - Paulauskis, Joe

AU - Bird, Jamie

AU - Warsinske, Lauren

AU - Chowdhury, Mahboob

AU - Davis, Dawson

AU - Meyers, Alyssa

AU - Lindsey, Kathleen

AU - Tutino, Rebecca

AU - Baker, Brittany

AU - Bolle, Charlotte

AU - Bratt, Debbie

AU - Briggs, Courtney

AU - Buescher, Lillian

AU - Burris, Jasmine

AU - Byrne, Jordan

AU - Carlock, Michael

AU - Fagan, Patrick

AU - Gattiker, Jasper

AU - Gokanapudi, Naveen

AU - Hamwy, Omar

AU - Hill, Tejal

AU - Howland, Lauren

AU - Ji, Hana

AU - Mailloux, Katie

AU - Phillips, Brad

AU - Schmitz, Kimberly

AU - Shi, Hua

AU - Smith, Cleopatria

AU - Waits, Terrie

AU - Whitesell, Emma

AU - Allen, E. Kaitlynn

AU - Allison, Kim

AU - Hakim, Hana

AU - Hayden, Randall T.

AU - Hijano, Diego R.

AU - Hoffman, James

AU - McGargill, Maureen A.

AU - Mori, Tomi

AU - Tang, Li

AU - Tuomanen, Elaine

AU - Webby, Richard

AU - Bajracharya, Resha

AU - Cherry, Sean

AU - Clark, Brandi L.

AU - Dallas, Ronald H.

AU - Fabrizio, Thomas

AU - Hodges, Jason

AU - Gowen, Ashleigh

AU - Lin, Chun Yang

AU - Russell-Bell, Jamie

AU - Sparks, James

AU - Wittman, David E.

AU - Van de Velde, Lee Ann

AU - Wilson, Taylor L.

AU - Roubidoux, Ericka Kirkpatrick

AU - Cortez, Valerie

AU - Freiden, Pamela

AU - Wohlgemuth, Nicholas

AU - Whitt, Kendall

AU - Farmaha, Jaspreet

AU - James, Jeffrey N.

AU - Carlock, Caroline Marie

AU - Fransoso, Drew

AU - Mondal, Ashis

AU - Sahajpal, Nikhil

AU - Churchwell, Lara

AU - Jones, Kimya

AU - Ananth, Sudha

AU - Williams, Colin

AU - Patel, Reeya

AU - Ray, Patty

AU - Danielle, Bradshaw

AU - Moore, Justin

AU - Flores, Evelyn

AU - Kupferwasser, Deborah

AU - Merino, Prudencio

AU - Tran, Donna Phan

AU - Jenkins, Meagan M.

AU - Bi, Qifang

PY - 2022/6

Y1 - 2022/6

N2 - To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARSCoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

AB - To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARSCoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

KW - COVID-19

KW - SARS-CoV-2

KW - antibodies

KW - cohort study

KW - reinfection

UR - http://www.scopus.com/inward/record.url?scp=85133214810&partnerID=8YFLogxK

U2 - 10.1128/msphere.00179-22

DO - 10.1128/msphere.00179-22

M3 - Article

C2 - 35586986

AN - SCOPUS:85133214810

SN - 2379-5042

VL - 7

JO - mSphere

JF - mSphere

IS - 3

ER -

PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2

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Keywords

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