@inproceedings{5a55deef1b90467faabc55c8049411d2,
title = "Parenchymal texture measures weighted by breast anatomy: Preliminary optimization in a case-control study",
abstract = "Growing evidence suggests that quantitative descriptors of the parenchymal texture patterns hold a valuable role in assessing an individual woman's risk for breast cancer. In this work, we assess the hypothesis that breast cancer risk factors are not uniformly expressed in the breast parenchymal tissue and, therefore, breast-anatomy-weighted parenchymal texture descriptors, where different breasts ROIs have non uniform contributions, may enhance breast cancer risk assessment. To this end, we introduce an automated breast-anatomy-driven methodology which generates a breast atlas, which is then used to produce a weight map that reinforces the contributions of the central and upper-outer breast areas. We incorporate this methodology to our previously validated lattice-based strategy for parenchymal texture analysis. In the framework of a pilot case-control study, including digital mammograms from 424 women, our proposed breast-anatomy-weighted texture descriptors are optimized and evaluated against non weighted texture features, using regression analysis with leave-one-out cross validation. The classification performance is assessed in terms of the area under the curve (AUC) of the receiver operating characteristic. The collective discriminatory capacity of the weighted texture features was maximized (AUC=0.87) when the central breast area was considered more important than the upperouter area, with significant performance improvement (DeLong's test, p-value<0.05) against the non-weighted texture features (AUC=0.82). Our results suggest that breast-anatomy-driven methodologies have the potential to further upgrade the promising role of parenchymal texture analysis in breast cancer risk assessment and may serve as a reference in the design of future studies towards image-driven personalized recommendations regarding women's cancer risk evaluation.",
keywords = "Breast anatomy, Breast cancer risk, Breast density, Digital mammography, Parenchymal texture",
author = "Aimilia Gastounioti and Keller, {Brad M.} and Hsieh, {Meng Kang} and Conant, {Emily F.} and Despina Kontos",
note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Medical Imaging 2016: Computer-Aided Diagnosis ; Conference date: 28-02-2016 Through 02-03-2016",
year = "2016",
doi = "10.1117/12.2217697",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Tourassi, {Georgia D.} and Armato, {Samuel G.}",
booktitle = "Medical Imaging 2016",
}