Parcellation in left lateral parietal cortex is similar in adults and children

Kelly Anne Barnes, Steven M. Nelson, Alexander L. Cohen, Jonathan D. Power, Rebecca S. Coalson, Francis M. Miezin, Alecia C. Vogel, Joseph W. Dubis, Jessica A. Church, Steven E. Petersen, Bradley L. Schlaggar

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity.

Original languageEnglish
Pages (from-to)1148-1158
Number of pages11
JournalCerebral Cortex
Volume22
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • brain development
  • functional areas
  • functional connectivity
  • parietal lobe

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