Parathyroid surgery in multiple endocrine neoplasia type 1

T. K. Pandian, Eee LN H. Buckarma, David R. Farley

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary hyperparathyroidism (PHPT) is the most common condition in patients with multiple endocrine neoplasia type 1 (MEN-1). Asymmetric, multi-gland disease due to multiple adenomas is characteristic in this cohort. The principal treatment of PHPT in MEN-1 patients is surgical. Options for surgical excision include subtotal (subPTX) or total parathyroidectomy with autotransplantation (totPTX). The optimal operation for these patients remains controversial. A 2011 systematic review and meta-analysis found no major difference in recurrence or persistence between subPTX and totPTX, but there were lower rates of hypocalcemia following subPTX. Recurrent PHPT in MEN-1 patients who have undergone initial parathyroidectomy is a challenging problem that should involve the input of experienced endocrine surgeons and endocrinologists. Alternative strategies such as alcohol ablation and cinacalcet administration may be warranted in some of these patients.

Original languageEnglish
Title of host publicationHyperparathyroidism
Subtitle of host publicationA Clinical Casebook
PublisherSpringer International Publishing
Pages75-85
Number of pages11
ISBN (Electronic)9783319258805
ISBN (Print)9783319258782
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Alcohol ablation
  • Autotransplantation
  • Cinacalcet
  • Multiple endocrine neoplasia 1
  • Primary hyperparathyroidism
  • Recurrent hyperparathyroidism
  • Subtotal parathyroidectomy
  • Total parathyroidectomy

Fingerprint Dive into the research topics of 'Parathyroid surgery in multiple endocrine neoplasia type 1'. Together they form a unique fingerprint.

  • Cite this

    Pandian, T. K., Buckarma, E. LN. H., & Farley, D. R. (2016). Parathyroid surgery in multiple endocrine neoplasia type 1. In Hyperparathyroidism: A Clinical Casebook (pp. 75-85). Springer International Publishing. https://doi.org/10.1007/978-3-319-25880-5_9