Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01)

Randall L. Duncan; Keith A. Hruska; Stanley Misler

doi:10.1016/0014-5793(92)80771-8

Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01)

Randall L. Duncan
, Keith A. Hruska
, Stanley Misler

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Cell-attached patches of membrane of osteoblast-like cells UMR-106.01 respond to bath application of parathyroid hormone (PTH) with an increase in the average activity, as well as the single channel conductance, of a stretch-activated non-selective cation channel. Correlations with whole cell membrane potential and conductance changes are considered.

Original language	English
Pages (from-to)	219-223
Number of pages	5
Journal	FEBS Letters
Volume	307
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(92)80771-8
State	Published - Jul 28 1992

Keywords

Cyclic AMP
Osteoblastic cell line
Parathyroid hormone
Stretch-activatcd channel

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10.1016/0014-5793(92)80771-8

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@article{506f08d081a3449c8299688ebc7c886e,

title = "Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01)",

abstract = "Cell-attached patches of membrane of osteoblast-like cells UMR-106.01 respond to bath application of parathyroid hormone (PTH) with an increase in the average activity, as well as the single channel conductance, of a stretch-activated non-selective cation channel. Correlations with whole cell membrane potential and conductance changes are considered.",

keywords = "Cyclic AMP, Osteoblastic cell line, Parathyroid hormone, Stretch-activatcd channel",

author = "Duncan, \{Randall L.\} and Hruska, \{Keith A.\} and Stanley Misler",

note = "Funding Information: Acknowledgements: This work was supported by funds from the National Institutes of Health (AR,39561, AR3\textasciitilde{}87, DK09976) and the Shriner\textasciitilde{} Hospital for Crippled Children (15952). S,M. is an Estab. liahed Investigator (1990--1995) of the American Heart Association, We thank the late Lee Falke for configuring and programming the data acq.uisitien/analysis system, Kevin Gillcs for advice and help with the histogram analysis and Louis Avioli for {\textcopyright}ncouraggment and discussion, We also thank Nicola C. Partridge for providing the initial \textasciitilde{}tock.\textasciitilde{} of UMR-106.01 cells and Ulises Alvarcz for maintaining the cultures,",

year = "1992",

month = jul,

day = "28",

doi = "10.1016/0014-5793(92)80771-8",

language = "English",

volume = "307",

pages = "219--223",

journal = "FEBS Letters",

issn = "0014-5793",

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TY - JOUR

T1 - Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01)

AU - Duncan, Randall L.

AU - Hruska, Keith A.

AU - Misler, Stanley

N1 - Funding Information: Acknowledgements: This work was supported by funds from the National Institutes of Health (AR,39561, AR3~87, DK09976) and the Shriner~ Hospital for Crippled Children (15952). S,M. is an Estab. liahed Investigator (1990--1995) of the American Heart Association, We thank the late Lee Falke for configuring and programming the data acq.uisitien/analysis system, Kevin Gillcs for advice and help with the histogram analysis and Louis Avioli for ©ncouraggment and discussion, We also thank Nicola C. Partridge for providing the initial ~tock.~ of UMR-106.01 cells and Ulises Alvarcz for maintaining the cultures,

PY - 1992/7/28

Y1 - 1992/7/28

N2 - Cell-attached patches of membrane of osteoblast-like cells UMR-106.01 respond to bath application of parathyroid hormone (PTH) with an increase in the average activity, as well as the single channel conductance, of a stretch-activated non-selective cation channel. Correlations with whole cell membrane potential and conductance changes are considered.

AB - Cell-attached patches of membrane of osteoblast-like cells UMR-106.01 respond to bath application of parathyroid hormone (PTH) with an increase in the average activity, as well as the single channel conductance, of a stretch-activated non-selective cation channel. Correlations with whole cell membrane potential and conductance changes are considered.

KW - Cyclic AMP

KW - Osteoblastic cell line

KW - Parathyroid hormone

KW - Stretch-activatcd channel

UR - https://www.scopus.com/pages/publications/0026711110

U2 - 10.1016/0014-5793(92)80771-8

DO - 10.1016/0014-5793(92)80771-8

M3 - Article

C2 - 1379539

AN - SCOPUS:0026711110

SN - 0014-5793

VL - 307

SP - 219

EP - 223

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01)

Abstract

Keywords

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