TY - JOUR
T1 - Parasitic nematodes-From genomes to control
AU - Mitreva, Makedonka
AU - Zarlenga, Dante S.
AU - McCarter, James P.
AU - Jasmer, Douglas P.
N1 - Funding Information:
This work was in part supported by NIH-NIAID research grant AI 46593.
PY - 2007/8/19
Y1 - 2007/8/19
N2 - The diseases caused by parasitic nematodes in domestic and companion animals are major factors that decrease production and quality of the agricultural products. Methods available for the control of the parasitic nematode infections are mainly based on chemical treatment, non-chemical management practices, immune modulation and biological control. However, even with integrated pest management that frequently combines these approaches, the effective and long-lasting control strategies are hampered by the persistent exposure of host animals to environmental stages of parasites, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic nematodes. Therefore, the challenges to improve control of parasitic nematode infections are multi-fold and no single category of information will meet them all. However, new information, such as nematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed to develop improvements. In this review we will, summarize existing control strategies of nematode infections and discuss ongoing developments in nematode genomics. Genomics approaches offer a growing and fundamental base of information, which when coupled with downstream functional genomics and proteomics can accelerate progress towards developing more efficient and sustainable control programs.
AB - The diseases caused by parasitic nematodes in domestic and companion animals are major factors that decrease production and quality of the agricultural products. Methods available for the control of the parasitic nematode infections are mainly based on chemical treatment, non-chemical management practices, immune modulation and biological control. However, even with integrated pest management that frequently combines these approaches, the effective and long-lasting control strategies are hampered by the persistent exposure of host animals to environmental stages of parasites, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic nematodes. Therefore, the challenges to improve control of parasitic nematode infections are multi-fold and no single category of information will meet them all. However, new information, such as nematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed to develop improvements. In this review we will, summarize existing control strategies of nematode infections and discuss ongoing developments in nematode genomics. Genomics approaches offer a growing and fundamental base of information, which when coupled with downstream functional genomics and proteomics can accelerate progress towards developing more efficient and sustainable control programs.
KW - Anthelmintics
KW - Expressed sequence tags
KW - Genetics
KW - Genomics
KW - Parasitic nematodes
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=34347339642&partnerID=8YFLogxK
U2 - 10.1016/j.vetpar.2007.05.008
DO - 10.1016/j.vetpar.2007.05.008
M3 - Article
C2 - 17560034
AN - SCOPUS:34347339642
SN - 0304-4017
VL - 148
SP - 31
EP - 42
JO - Veterinary Parasitology
JF - Veterinary Parasitology
IS - 1 SPEC. ISS.
ER -