Paraneoplastic myopathy: response to intravenous immunoglobulin

J. B. Sampson, S. M. Smith, A. G. Smith, J. R. Singleton, S. Chin, A. Pestronk, K. M. Flanigan

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Necrotizing myopathy is an unusual and severe form of paraneoplastic myopathy in which inflammation is minimal or absent. We report two cases of necrotizing myopathy which demonstrated significant response to intravenous immunoglobulin (IVIG) (one in spite of tumor progression). A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer. These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalNeuromuscular Disorders
Issue number5
StatePublished - May 1 2007


  • Anti-SRP
  • Intravenous immunoglobulin
  • Necrotizing myopathy
  • Paraneoplastic myopathy


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