Paraneoplastic myopathy: response to intravenous immunoglobulin

J. B. Sampson; S. M. Smith; A. G. Smith; J. R. Singleton; S. Chin; A. Pestronk; K. M. Flanigan

doi:10.1016/j.nmd.2007.01.004

Paraneoplastic myopathy: response to intravenous immunoglobulin

J. B. Sampson, S. M. Smith, A. G. Smith, J. R. Singleton, S. Chin, A. Pestronk, K. M. Flanigan

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46 Scopus citations

Abstract

Necrotizing myopathy is an unusual and severe form of paraneoplastic myopathy in which inflammation is minimal or absent. We report two cases of necrotizing myopathy which demonstrated significant response to intravenous immunoglobulin (IVIG) (one in spite of tumor progression). A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer. These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.

Original language	English
Pages (from-to)	404-408
Number of pages	5
Journal	Neuromuscular Disorders
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.nmd.2007.01.004
State	Published - May 2007

Keywords

Anti-SRP
Intravenous immunoglobulin
Necrotizing myopathy
Paraneoplastic myopathy

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title = "Paraneoplastic myopathy: response to intravenous immunoglobulin",

abstract = "Necrotizing myopathy is an unusual and severe form of paraneoplastic myopathy in which inflammation is minimal or absent. We report two cases of necrotizing myopathy which demonstrated significant response to intravenous immunoglobulin (IVIG) (one in spite of tumor progression). A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer. These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.",

keywords = "Anti-SRP, Intravenous immunoglobulin, Necrotizing myopathy, Paraneoplastic myopathy",

author = "Sampson, {J. B.} and Smith, {S. M.} and Smith, {A. G.} and Singleton, {J. R.} and S. Chin and A. Pestronk and Flanigan, {K. M.}",

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T2 - response to intravenous immunoglobulin

AU - Sampson, J. B.

AU - Smith, S. M.

AU - Smith, A. G.

AU - Singleton, J. R.

AU - Chin, S.

AU - Pestronk, A.

AU - Flanigan, K. M.

PY - 2007/5

Y1 - 2007/5

N2 - Necrotizing myopathy is an unusual and severe form of paraneoplastic myopathy in which inflammation is minimal or absent. We report two cases of necrotizing myopathy which demonstrated significant response to intravenous immunoglobulin (IVIG) (one in spite of tumor progression). A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer. These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.

AB - Necrotizing myopathy is an unusual and severe form of paraneoplastic myopathy in which inflammation is minimal or absent. We report two cases of necrotizing myopathy which demonstrated significant response to intravenous immunoglobulin (IVIG) (one in spite of tumor progression). A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer. These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.

KW - Anti-SRP

KW - Intravenous immunoglobulin

KW - Necrotizing myopathy

KW - Paraneoplastic myopathy

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M3 - Article

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AN - SCOPUS:34247588229

SN - 0960-8966

VL - 17

SP - 404

EP - 408

JO - Neuromuscular Disorders

JF - Neuromuscular Disorders

IS - 5

ER -

Paraneoplastic myopathy: response to intravenous immunoglobulin

Abstract

Keywords

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