TY - JOUR
T1 - Parallel hippocampal-parietal circuits for self- And goal-oriented processing
AU - Zheng, Annie
AU - Montez, David F.
AU - Marek, Scott
AU - Gilmore, Adrian W.
AU - Newbold, Dillan J.
AU - Laumann, Timothy O.
AU - Kay, Benjamin P.
AU - Seider, Nicole A.
AU - Van, Andrew N.
AU - Hampton, Jacqueline M.
AU - Alexopoulos, Dimitrios
AU - Schlaggar, Bradley L.
AU - Sylvester, Chad M.
AU - Greene, Deanna J.
AU - Shimony, Joshua S.
AU - Nelson, Steven M.
AU - Wig, Gagan S.
AU - Gratton, Caterina
AU - McDermott, Kathleen B.
AU - Raichle, Marcus E.
AU - Gordon, Evan M.
AU - Dosenbach, Nico U.F.
N1 - Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.
PY - 2021/8/24
Y1 - 2021/8/24
N2 - The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior–posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.
AB - The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior–posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.
KW - Brain networks
KW - Functional connectivity
KW - Hippocampus
KW - Individual variability
KW - Resting state
UR - http://www.scopus.com/inward/record.url?scp=85113347372&partnerID=8YFLogxK
U2 - 10.1073/pnas.2101743118
DO - 10.1073/pnas.2101743118
M3 - Article
C2 - 34404728
AN - SCOPUS:85113347372
SN - 0027-8424
VL - 118
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 34
M1 - e2101743118
ER -