TY - JOUR
T1 - Paracrine WNT5A signaling in healthy and neoplastic mammary tissue
AU - Kusner, David
AU - Borcherding, Nicholas
AU - Zhang, Weizhou
N1 - Publisher Copyright:
© 2016, © 2016 Taylor & Francis Group, LLC.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.
AB - Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.
KW - Breast cancer
KW - mammary development
KW - Noncanonical WNT
KW - WNT5A signaling
UR - http://www.scopus.com/inward/record.url?scp=85050716517&partnerID=8YFLogxK
U2 - 10.1080/23723556.2015.1040145
DO - 10.1080/23723556.2015.1040145
M3 - Article
AN - SCOPUS:85050716517
SN - 2372-3556
VL - 3
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 1
M1 - e1040145
ER -