TY - JOUR
T1 - PapD-like chaperones and pilus biogenesis
AU - Sauer, Frederic G.
AU - Knight, Stefan D.
AU - Waksman and, Gabriel J.
AU - Hultgren, Scott J.
PY - 2000
Y1 - 2000
N2 - The assembly of adhesive pili from individual subunits by periplasmic PapD-like chaperones in Gram-negative bacteria offers insight into the complex process of organelle biogenesis. PapD-like chaperones bind, stabilize, and cap interactive surfaces of subunits until they are assembled into the pilus. Subunits lack the seventh β-strand necessary to complete their immunoglobulin-like folds; the chaperone supplies this missing strand. Indeed, the chaperone may act as a template, providing steric information to facilitate subunit folding. In the mature pilus, each subunit is thought to supply the missing strand to complete the fold of its neighbor. Thus, one general function of chaperones in organelle biogenesis may be to cap highly interactive surfaces of subunits until they reach the proper assembly site.
AB - The assembly of adhesive pili from individual subunits by periplasmic PapD-like chaperones in Gram-negative bacteria offers insight into the complex process of organelle biogenesis. PapD-like chaperones bind, stabilize, and cap interactive surfaces of subunits until they are assembled into the pilus. Subunits lack the seventh β-strand necessary to complete their immunoglobulin-like folds; the chaperone supplies this missing strand. Indeed, the chaperone may act as a template, providing steric information to facilitate subunit folding. In the mature pilus, each subunit is thought to supply the missing strand to complete the fold of its neighbor. Thus, one general function of chaperones in organelle biogenesis may be to cap highly interactive surfaces of subunits until they reach the proper assembly site.
KW - Chaperone
KW - Organelle biogenesis
KW - Pilus
KW - Protein folding
UR - http://www.scopus.com/inward/record.url?scp=0034488543&partnerID=8YFLogxK
U2 - 10.1006/scdb.1999.0348
DO - 10.1006/scdb.1999.0348
M3 - Article
C2 - 10736261
AN - SCOPUS:0034488543
VL - 11
SP - 27
EP - 34
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
IS - 1
ER -