TY - JOUR
T1 - Panton-valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease
AU - Wardenburg, Juliane Bubeck
AU - Palazzolo-Ballance, Amy M.
AU - Otto, Michael
AU - Schneewind, Olaf
AU - DeLeo, Frank R.
N1 - Funding Information:
Financial support: Intramural Research Program, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Division of Microbiology and Infectious Diseases, NIAID (grant AI52747 to O.S.). J.B.W. is a National Institute of Child Health and Human Development (NICHD) Fellow of the Pediatric Scientist Development Program (NICHD grant K12-HD00850).
PY - 2008/10/15
Y1 - 2008/10/15
N2 - Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.
AB - Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CAMRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.
UR - http://www.scopus.com/inward/record.url?scp=54749153168&partnerID=8YFLogxK
U2 - 10.1086/592053
DO - 10.1086/592053
M3 - Article
C2 - 18729780
AN - SCOPUS:54749153168
SN - 0022-1899
VL - 198
SP - 1166
EP - 1170
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -