Panglobal distribution of a single clonal lineage of the Irish potato famine fungus

Stephen B. Goodwin, Barak A. Cohen, William E. Fry

Research output: Contribution to journalArticle

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Abstract

More than 300 isolates of the Irish potato famine fungus, Phytophthora infestans, collected in 20 countries on five continents, were analyzed for genetic variation at the mating type and two allozyme loci. A subset of more than 200 isolates was also analyzed for DNA 'fingerprint' variation. A surprising result was that a single clonal lineage dominated most populations worldwide. All of the variation within this lineage appeared to have arisen by mitotic recombination or by mutation. In addition to the most common clonal lineage, a number of different, but apparently closely related, lineages occurred in the United States and Canada. The low levels of gene diversity in the derived populations compared to the presumed ancestral population in central Mexico indicate that P. infestans went through extreme genetic bottlenecks during its dispersal. The genetic data are consistent with the hypothesis that the initial migration of P. infestans in the 1840s was from Mexico to the United States and that only a single genetic individual was transported to Europe and subsequently to the rest of the world. If this hypothesis is correct, then the Irish potato famine was caused by a single clonal genotype of P. infestans.

Original languageEnglish
Pages (from-to)11591-11595
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number24
DOIs
StatePublished - Nov 22 1994
Externally publishedYes

Keywords

  • DNA fingerprinting
  • Phytophthora infestans
  • bottlenecks
  • founder effects
  • migration

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