Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects

S. Klein, V. R. Young, G. L. Blackburn, B. R. Bistrian, R. R. Wolfe

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Data obtained in vitro suggest that the ability to mobilize fat decreases with age. We determined lipolytic rates in vivo in normal weight young adult (22-33 yr) and elderly (65-77 yr) subjects using a simultaneous infusion of [1,2-13C2]palmitate and [2H5]glycerol. The subjects were studied after a 12-h fast and again after 60-82 h of fasting. When lipolysis was expressed per unit of adipose tissue the values for the young adults were more than double those for the elderly (P < 0.05). However, the amount of body fat in the elderly was twice that of the young adults, so that lipolysis per unit of body weight was similar in both groups. These results demonstrate that lipolysis per unit of adipose tissue is lower in elderly subjects. This may be due to their increase in body fat, however, since the total amount of potential energy mobilized from adipose tissue was similar to that of the young adults.

Original languageEnglish
Pages (from-to)928-933
Number of pages6
JournalJournal of Clinical Investigation
Volume78
Issue number4
DOIs
StatePublished - 1986

Fingerprint Dive into the research topics of 'Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects'. Together they form a unique fingerprint.

Cite this