Pallbearer and friends: lending a hand in apoptotic cell clearance

Michael R. Elliott, Kodi S. Ravichandran

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Engulfment and prompt removal of apoptotic cells occurs from embryogenesis throughout the lifespan of multicellular organisms. A new player, Pallbearer, has recently been identified in Drosophila as being important for efficient engulfment by macrophages. Pallbearer is a component of the SCF E3 ubiquitin ligase complex involved in the ubiquitylation of proteins targeted for proteasomal degradation. This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalTrends in Cell Biology
Issue number3
StatePublished - Mar 2008


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