TY - JOUR
T1 - Pallbearer and friends
T2 - lending a hand in apoptotic cell clearance
AU - Elliott, Michael R.
AU - Ravichandran, Kodi S.
N1 - Funding Information:
We acknowledge the many investigators whose relevant work in the engulfment field we were unable to cite due to space limitations. M.R.E. is supported by fellowships from the American Cancer Society and The University of Virginia Farrow Fellowship. K.S.R. acknowledges support through grants from the NIGMS/NIH.
PY - 2008/3
Y1 - 2008/3
N2 - Engulfment and prompt removal of apoptotic cells occurs from embryogenesis throughout the lifespan of multicellular organisms. A new player, Pallbearer, has recently been identified in Drosophila as being important for efficient engulfment by macrophages. Pallbearer is a component of the SCF E3 ubiquitin ligase complex involved in the ubiquitylation of proteins targeted for proteasomal degradation. This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently.
AB - Engulfment and prompt removal of apoptotic cells occurs from embryogenesis throughout the lifespan of multicellular organisms. A new player, Pallbearer, has recently been identified in Drosophila as being important for efficient engulfment by macrophages. Pallbearer is a component of the SCF E3 ubiquitin ligase complex involved in the ubiquitylation of proteins targeted for proteasomal degradation. This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently.
UR - http://www.scopus.com/inward/record.url?scp=39949083198&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2007.12.005
DO - 10.1016/j.tcb.2007.12.005
M3 - Short survey
C2 - 18280734
AN - SCOPUS:39949083198
SN - 0962-8924
VL - 18
SP - 95
EP - 97
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 3
ER -