Pain sensitization

Y. Carrasquillo; R. W. Gereau

doi:10.1016/B978-012370509-9.00007-3

Pain sensitization

Y. Carrasquillo, R. W. Gereau

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The classic view of pain as a labeled line sensation has been debunked by the understanding that pain is highly modified by experience. The experience-dependent enhancement of pain sensation can be viewed as a form of learning, and these memories of pain are both unwanted and difficult to forget. In this chapter, we discuss the variety of mechanisms of sensitization in the pain neuraxis, and their surprising similarity to mechanisms of classical learning and memory. These similarities create both unique insight into the problem of persistent pain and unique challenges for designing novel pharmacotherapies for its treatment.

Original language	English
Title of host publication	Learning and Memory
Subtitle of host publication	A Comprehensive Reference
Publisher	Elsevier
Pages	65-90
Number of pages	26
ISBN (Electronic)	9780123705099
DOIs	https://doi.org/10.1016/B978-012370509-9.00007-3
State	Published - Jan 1 2007

Keywords

Amygdala
Analgesia
Anterior cingulate cortex
Avoidance
Central sensitization
Cognition
Emotions
LTP
Learning
Long-term potentiation
Memory
Nociception
Nociceptor
Pain
Sensitization
Windup

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10.1016/B978-012370509-9.00007-3

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title = "Pain sensitization",

abstract = "The classic view of pain as a labeled line sensation has been debunked by the understanding that pain is highly modified by experience. The experience-dependent enhancement of pain sensation can be viewed as a form of learning, and these memories of pain are both unwanted and difficult to forget. In this chapter, we discuss the variety of mechanisms of sensitization in the pain neuraxis, and their surprising similarity to mechanisms of classical learning and memory. These similarities create both unique insight into the problem of persistent pain and unique challenges for designing novel pharmacotherapies for its treatment.",

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AB - The classic view of pain as a labeled line sensation has been debunked by the understanding that pain is highly modified by experience. The experience-dependent enhancement of pain sensation can be viewed as a form of learning, and these memories of pain are both unwanted and difficult to forget. In this chapter, we discuss the variety of mechanisms of sensitization in the pain neuraxis, and their surprising similarity to mechanisms of classical learning and memory. These similarities create both unique insight into the problem of persistent pain and unique challenges for designing novel pharmacotherapies for its treatment.

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KW - Analgesia

KW - Anterior cingulate cortex

KW - Avoidance

KW - Central sensitization

KW - Cognition

KW - Emotions

KW - LTP

KW - Learning

KW - Long-term potentiation

KW - Memory

KW - Nociception

KW - Nociceptor

KW - Pain

KW - Sensitization

KW - Windup

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M3 - Chapter

AN - SCOPUS:70449588214

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EP - 90

BT - Learning and Memory

PB - Elsevier

ER -

Pain sensitization

Abstract

Keywords

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