Abstract
The classic view of pain as a labeled line sensation has been debunked by the understanding that pain is highly modified by experience. The experience-dependent enhancement of pain sensation can be viewed as a form of learning, and these memories of pain are both unwanted and difficult to forget. In this chapter, we discuss the variety of mechanisms of sensitization in the pain neuraxis, and their surprising similarity to mechanisms of classical learning and memory. These similarities create both unique insight into the problem of persistent pain and unique challenges for designing novel pharmacotherapies for its treatment.
| Original language | English |
|---|---|
| Title of host publication | Learning and Memory |
| Subtitle of host publication | A Comprehensive Reference |
| Publisher | Elsevier |
| Pages | 65-90 |
| Number of pages | 26 |
| ISBN (Electronic) | 9780123705099 |
| DOIs | |
| State | Published - Jan 1 2007 |
Keywords
- Amygdala
- Analgesia
- Anterior cingulate cortex
- Avoidance
- Central sensitization
- Cognition
- Emotions
- LTP
- Learning
- Long-term potentiation
- Memory
- Nociception
- Nociceptor
- Pain
- Sensitization
- Windup
Fingerprint Dive into the research topics of 'Pain sensitization'. Together they form a unique fingerprint.
Cite this
Carrasquillo, Y., & Gereau, R. W. (2007). Pain sensitization. In Learning and Memory: A Comprehensive Reference (pp. 65-90). Elsevier. https://doi.org/10.1016/B978-012370509-9.00007-3