@article{8e8009fa5fb74890a0bb4efd5810d878,
title = "Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior",
abstract = "The persistence of negative affect in pain leads to co-morbid symptoms such as anhedonia and depression—major health issues in the United States. The neuronal circuitry and contribution of specific cellular populations underlying these behavioral adaptations remains unknown. A common characteristic of negative affect is a decrease in motivation to initiate and complete goal-directed behavior, known as anhedonia. We report that in rodents, inflammatory pain decreased the activity of ventral tegmental area (VTA) dopamine (DA) neurons, which are critical mediators of motivational states. Pain increased rostromedial tegmental nucleus inhibitory tone onto VTA DA neurons, making them less excitable. Furthermore, the decreased activity of DA neurons was associated with reduced motivation for natural rewards, consistent with anhedonia-like behavior. Selective activation of VTA DA neurons was sufficient to restore baseline motivation and hedonic responses to natural rewards. These findings reveal pain-induced adaptations within VTA DA neurons that underlie anhedonia-like behavior.",
author = "Tamara Markovic and Pedersen, {Christian E.} and Nicolas Massaly and Vachez, {Yvan M.} and Brian Ruyle and Murphy, {Caitlin A.} and Kavitha Abiraman and Shin, {Jung Hoon} and Garcia, {Jeniffer J.} and Yoon, {Hye Jean} and Alvarez, {Veronica A.} and Bruchas, {Michael R.} and Creed, {Meaghan C.} and Mor{\'o}n, {Jose A.}",
note = "Funding Information: We would like to thank all members from the Moron-Concepcion, Bruchas, Creed and Alvarez laboratories for their help throughout the completion of the current study. In addition, we thank I. Monosov for help with statistical analysis for Fig. 3i,j,k, and A. R. Wilson-Poe for manuscript review and editing. This work was supported by US National Institutes of Health (NIH) grants DA041781 (to J.A.M.), DA042581 (to J.A.M.), DA042499 (to J.A.M.), DA041883 (to J.A.M.) and DA045463 (to J.A.M.), a NARSAD Independent Investigator Award from the Brain and Behavior Research Foundation (to J.A.M.), the Brain and Behavior Research Foundation (NARSAD Young Investigator grant 27197 to M.C.C.), National Institutes of Health National Institute on Drug Abuse R21-DA047127 (to M.C.C.) and R01-DA049924 (to M.C.C.), Whitehall Foundation grant 2017-12-54 (to M.C.C.), a Rita Allen Scholar Award in Pain (to M.C.C.), and NRSA F31DA051124 (to C.E.P.). Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2021",
month = nov,
doi = "10.1038/s41593-021-00924-3",
language = "English",
volume = "24",
pages = "1601--1613",
journal = "Nature Neuroscience",
issn = "1097-6256",
number = "11",
}