Pain in Multiple Sclerosis

David B. Clifford, John L. Trotter

Research output: Contribution to journalArticlepeer-review

163 Scopus citations


We reviewed 317 patients with multiple sclerosis (MS) and found that the incidence of clinically significant pain, excluding headache and paresthesia, was 28.8%. Successful treatment requires recognition of the pathophysiology of the pain syndromes encountered in MS. Antidepressant drugs have been of particular value in the treatment of chronic pain in these patients.

Original languageEnglish
Pages (from-to)1270-1272
Number of pages3
JournalArchives of neurology
Issue number12
StatePublished - Dec 1984


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