Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Pankaj Baral; Kimbria Mills; Felipe A. Pinho-Ribeiro; Isaac M. Chiu

doi:10.1016/j.chom.2016.05.010

Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Pankaj Baral
, Kimbria Mills
, Felipe A. Pinho-Ribeiro
, Isaac M. Chiu

Research output: Contribution to journal › Comment/debate

24 Scopus citations

Abstract

Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.

Original language	English
Pages (from-to)	755-759
Number of pages	5
Journal	Cell Host and Microbe
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2016.05.010
State	Published - Jun 8 2016

Keywords

host defense
itch
neuroimmunology
pain

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10.1016/j.chom.2016.05.010

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title = "Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?",

abstract = "Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.",

keywords = "host defense, itch, neuroimmunology, pain",

author = "Pankaj Baral and Kimbria Mills and Pinho-Ribeiro, \{Felipe A.\} and Chiu, \{Isaac M.\}",

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AU - Baral, Pankaj

AU - Mills, Kimbria

AU - Pinho-Ribeiro, Felipe A.

AU - Chiu, Isaac M.

PY - 2016/6/8

Y1 - 2016/6/8

N2 - Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.

AB - Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.

KW - host defense

KW - itch

KW - neuroimmunology

KW - pain

UR - https://www.scopus.com/pages/publications/84973452515

U2 - 10.1016/j.chom.2016.05.010

DO - 10.1016/j.chom.2016.05.010

M3 - Comment/debate

C2 - 27281567

AN - SCOPUS:84973452515

SN - 1931-3128

VL - 19

SP - 755

EP - 759

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Abstract

Keywords

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