Paget's disease of bone

Michael P. Whyte

doi:10.1056/NEJMcp060278

Paget's disease of bone

Michael P. Whyte

Research output: Contribution to journal › Article › peer-review

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Abstract

A 69-year-old man reports increasing pain in the right leg. Physical examination reveals warmth and anterolateral bowing of the right shin. The serum alkaline phosphatase level is 260 U per liter (normal, 38 to 126 U per liter). A skeletal scintigraphic scan reveals enhanced uptake in only the deformed tibia, where a radiograph shows changes indicative of Paget's disease. His sister, whose alkaline phosphatase level is 160 U per liter, has asymptomatic Paget's disease confined to the left iliac wing. How should their conditions be managed?

Original language	English
Pages (from-to)	593-600
Number of pages	8
Journal	New England Journal of Medicine
Volume	355
Issue number	6
DOIs	https://doi.org/10.1056/NEJMcp060278
State	Published - Aug 10 2006

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10.1056/NEJMcp060278

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title = "Paget's disease of bone",

abstract = "A 69-year-old man reports increasing pain in the right leg. Physical examination reveals warmth and anterolateral bowing of the right shin. The serum alkaline phosphatase level is 260 U per liter (normal, 38 to 126 U per liter). A skeletal scintigraphic scan reveals enhanced uptake in only the deformed tibia, where a radiograph shows changes indicative of Paget's disease. His sister, whose alkaline phosphatase level is 160 U per liter, has asymptomatic Paget's disease confined to the left iliac wing. How should their conditions be managed?",

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N2 - A 69-year-old man reports increasing pain in the right leg. Physical examination reveals warmth and anterolateral bowing of the right shin. The serum alkaline phosphatase level is 260 U per liter (normal, 38 to 126 U per liter). A skeletal scintigraphic scan reveals enhanced uptake in only the deformed tibia, where a radiograph shows changes indicative of Paget's disease. His sister, whose alkaline phosphatase level is 160 U per liter, has asymptomatic Paget's disease confined to the left iliac wing. How should their conditions be managed?

AB - A 69-year-old man reports increasing pain in the right leg. Physical examination reveals warmth and anterolateral bowing of the right shin. The serum alkaline phosphatase level is 260 U per liter (normal, 38 to 126 U per liter). A skeletal scintigraphic scan reveals enhanced uptake in only the deformed tibia, where a radiograph shows changes indicative of Paget's disease. His sister, whose alkaline phosphatase level is 160 U per liter, has asymptomatic Paget's disease confined to the left iliac wing. How should their conditions be managed?

UR - https://www.scopus.com/pages/publications/33746897394

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DO - 10.1056/NEJMcp060278

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VL - 355

SP - 593

EP - 600

JO - New England Journal of Medicine

JF - New England Journal of Medicine

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Paget's disease of bone

Abstract

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