Abstract
A 69-year-old man reports increasing pain in the right leg. Physical examination reveals warmth and anterolateral bowing of the right shin. The serum alkaline phosphatase level is 260 U per liter (normal, 38 to 126 U per liter). A skeletal scintigraphic scan reveals enhanced uptake in only the deformed tibia, where a radiograph shows changes indicative of Paget's disease. His sister, whose alkaline phosphatase level is 160 U per liter, has asymptomatic Paget's disease confined to the left iliac wing. How should their conditions be managed?
| Original language | English |
|---|---|
| Pages (from-to) | 593-600 |
| Number of pages | 8 |
| Journal | New England Journal of Medicine |
| Volume | 355 |
| Issue number | 6 |
| DOIs | |
| State | Published - Aug 10 2006 |