Pachydermoperiostosis: studies on the synovium.

S. A. Lauter, F. B. Vasey, I. Hüttner, C. K. Osterland

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Pachydermoperiostosis (primary hypertrophic osteoarthropathy) is a familial disorder characterized by clubbing, periosteal bone changes, and furrowing of the skin. A 40 year old male with this syndrome and chronic arthritis was recently studied. The synovial fluid was non-inflammatory. Histologically the synovium exhibited hyperplasia and microvascular alterations. Immunofluorescent staining failed to identify deposits of immunoglobulin. Electron microscopy revealed multilayered basement laminae around small subsynovial blood vessels but no electron-dense deposits as described in studies of hypertrophic pulmonary osteoarthropathy. The pathogenesis is obscure and appears to be non-immunological.

Original languageEnglish
Pages (from-to)85-95
Number of pages11
JournalJournal of Rheumatology
Issue number1
StatePublished - Mar 1 1978
Externally publishedYes


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