Abstract
Pachydermoperiostosis (primary hypertrophic osteoarthropathy) is a familial disorder characterized by clubbing, periosteal bone changes, and furrowing of the skin. A 40 year old male with this syndrome and chronic arthritis was recently studied. The synovial fluid was non-inflammatory. Histologically the synovium exhibited hyperplasia and microvascular alterations. Immunofluorescent staining failed to identify deposits of immunoglobulin. Electron microscopy revealed multilayered basement laminae around small subsynovial blood vessels but no electron-dense deposits as described in studies of hypertrophic pulmonary osteoarthropathy. The pathogenesis is obscure and appears to be non-immunological.
| Original language | English |
|---|---|
| Pages (from-to) | 85-95 |
| Number of pages | 11 |
| Journal | Journal of Rheumatology |
| Volume | 5 |
| Issue number | 1 |
| State | Published - Mar 1 1978 |
| Externally published | Yes |