p66shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone

Amy M. Kleman; Jacquelynn E. Brown; Stephanie L.H. Zeiger; Jane C. Hettinger; Joshua D. Brooks; Benjamin Holt; Jason D. Morrow; Erik S. Musiek; Ginger L. Milne; Beth Ann McLaughlin

doi:10.4161/auto.6.7.13007

p66^shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone

Amy M. Kleman, Jacquelynn E. Brown, Stephanie L.H. Zeiger, Jane C. Hettinger, Joshua D. Brooks, Benjamin Holt, Jason D. Morrow, Erik S. Musiek, Ginger L. Milne, Beth Ann McLaughlin

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling in mediating mitophagy and determining neuronal cell fate following acute oxygen glucose deprivation.

Original language	English
Pages (from-to)	948-949
Number of pages	2
Journal	Autophagy
Volume	6
Issue number	7
DOIs	https://doi.org/10.4161/auto.6.7.13007
State	Published - Oct 1 2010

Keywords

Hypoxia
Ischemia
Mitochondria
Mitophagy
Neurodegeneration
Preconditioning

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title = "p66shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone",

abstract = "Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling in mediating mitophagy and determining neuronal cell fate following acute oxygen glucose deprivation.",

keywords = "Hypoxia, Ischemia, Mitochondria, Mitophagy, Neurodegeneration, Preconditioning",

author = "Kleman, {Amy M.} and Brown, {Jacquelynn E.} and Zeiger, {Stephanie L.H.} and Hettinger, {Jane C.} and Brooks, {Joshua D.} and Benjamin Holt and Morrow, {Jason D.} and Musiek, {Erik S.} and Milne, {Ginger L.} and McLaughlin, {Beth Ann}",

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T1 - p66shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone

AU - Kleman, Amy M.

AU - Brown, Jacquelynn E.

AU - Zeiger, Stephanie L.H.

AU - Hettinger, Jane C.

AU - Brooks, Joshua D.

AU - Holt, Benjamin

AU - Morrow, Jason D.

AU - Musiek, Erik S.

AU - Milne, Ginger L.

AU - McLaughlin, Beth Ann

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling in mediating mitophagy and determining neuronal cell fate following acute oxygen glucose deprivation.

AB - Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling in mediating mitophagy and determining neuronal cell fate following acute oxygen glucose deprivation.

KW - Hypoxia

KW - Ischemia

KW - Mitochondria

KW - Mitophagy

KW - Neurodegeneration

KW - Preconditioning

UR - http://www.scopus.com/inward/record.url?scp=77957675334&partnerID=8YFLogxK

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DO - 10.4161/auto.6.7.13007

M3 - Short survey

C2 - 20724835

AN - SCOPUS:77957675334

SN - 1554-8627

VL - 6

SP - 948

EP - 949

JO - Autophagy

JF - Autophagy

IS - 7

ER -

p66^shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone

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Keywords

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