p53 Protects Cells from Death at the Heatstroke Threshold Temperature

Lu Gong; Qinghe Zhang; Xiao Pan; Shuming Chen; Lina Yang; Bin Liu; Weijun Yang; Luyang Yu; Zhi Xiong Xiao; Xin Hua Feng; Haihe Wang; Zhi Min Yuan; Jinrong Peng; Wei Qiang Tan; Jun Chen

doi:10.1016/j.celrep.2019.11.032

p53 Protects Cells from Death at the Heatstroke Threshold Temperature

Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi Xiong Xiao, Xin Hua Feng, Haihe Wang, Zhi Min Yuan, Jinrong Peng, Wei Qiang Tan, Jun Chen

Division of Pulmonary & Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Gong et al. report that in contrast to promoting apoptosis in hyperthermia conditions, both zebrafish and human tumor repressor p53 protect cells from death by preventing a hyperreactive heat shock response at 40°C, the heatstroke threshold temperature (HTT). They may provide a strategy for individualized therapy for p53-deficient cancers.

Original language	English
Pages (from-to)	3693-3707.e5
Journal	Cell Reports
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.11.032
State	Published - Dec 10 2019

Keywords

ATM
cell death
heatstroke threshold temperature
Hsc70
Hsf1
Hsp90
human cell
hyperthermia temperature
p53
zebrafish

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10.1016/j.celrep.2019.11.032

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title = "p53 Protects Cells from Death at the Heatstroke Threshold Temperature",

abstract = "Gong et al. report that in contrast to promoting apoptosis in hyperthermia conditions, both zebrafish and human tumor repressor p53 protect cells from death by preventing a hyperreactive heat shock response at 40°C, the heatstroke threshold temperature (HTT). They may provide a strategy for individualized therapy for p53-deficient cancers.",

keywords = "ATM, cell death, heatstroke threshold temperature, Hsc70, Hsf1, Hsp90, human cell, hyperthermia temperature, p53, zebrafish",

author = "Lu Gong and Qinghe Zhang and Xiao Pan and Shuming Chen and Lina Yang and Bin Liu and Weijun Yang and Luyang Yu and Xiao, {Zhi Xiong} and Feng, {Xin Hua} and Haihe Wang and Yuan, {Zhi Min} and Jinrong Peng and Tan, {Wei Qiang} and Jun Chen",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

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day = "10",

doi = "10.1016/j.celrep.2019.11.032",

language = "English",

volume = "29",

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TY - JOUR

T1 - p53 Protects Cells from Death at the Heatstroke Threshold Temperature

AU - Gong, Lu

AU - Zhang, Qinghe

AU - Pan, Xiao

AU - Chen, Shuming

AU - Yang, Lina

AU - Liu, Bin

AU - Yang, Weijun

AU - Yu, Luyang

AU - Xiao, Zhi Xiong

AU - Feng, Xin Hua

AU - Wang, Haihe

AU - Yuan, Zhi Min

AU - Peng, Jinrong

AU - Tan, Wei Qiang

AU - Chen, Jun

PY - 2019/12/10

Y1 - 2019/12/10

N2 - Gong et al. report that in contrast to promoting apoptosis in hyperthermia conditions, both zebrafish and human tumor repressor p53 protect cells from death by preventing a hyperreactive heat shock response at 40°C, the heatstroke threshold temperature (HTT). They may provide a strategy for individualized therapy for p53-deficient cancers.

AB - Gong et al. report that in contrast to promoting apoptosis in hyperthermia conditions, both zebrafish and human tumor repressor p53 protect cells from death by preventing a hyperreactive heat shock response at 40°C, the heatstroke threshold temperature (HTT). They may provide a strategy for individualized therapy for p53-deficient cancers.

KW - ATM

KW - cell death

KW - heatstroke threshold temperature

KW - Hsc70

KW - Hsf1

KW - Hsp90

KW - human cell

KW - hyperthermia temperature

KW - p53

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85075974700&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.11.032

DO - 10.1016/j.celrep.2019.11.032

M3 - Article

C2 - 31825845

AN - SCOPUS:85075974700

SN - 2639-1856

VL - 29

SP - 3693-3707.e5

JO - Cell Reports

JF - Cell Reports

IS - 11

ER -

p53 Protects Cells from Death at the Heatstroke Threshold Temperature

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Keywords

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