Oxytocin and Oxytocinase in the Obese and Nonobese Parturients during Induction and Augmentation of Labor

Annemaria De Tina, Jeremy Juang, Thomas F. McElrath, Jack D. Baty, Arvind Palanisamy

Research output: Contribution to journalArticle

Abstract

Objective To investigate differences in oxytocin (OXT) biodistribution between nonobese and obese parturients during labor. Study Design Patients with body mass index (BMI) of either ≥ 18 ≤ 24.9 kg/m 2 (nonobese) or ≥ 30 kg/m 2 (obese) undergoing elective induction of labor were included (N = 25 each). Blood samples were collected at baseline (T 0), and 20 minutes after maximal OXT augmentation or adequate uterine contractions (T 1) for OXT and oxytocinase assays. A mixed-model repeated-measures analysis of variance was used to test for group versus time interaction and analysis of covariance to detect a difference in OXT level at T 1. Data presented as mean ± standard deviation or median (interquartile range), with p < 0.05 considered significant. Results The mean BMIs (kg/m 2) were 22.1 ± 1.6 and 35.9 ± 5.1 in the nonobese and obese groups, respectively. No differences were observed in either the duration of OXT infusion, total dose of OXT, or plasma OXT (pg/mL) either at T 0 or T 1. However, plasma oxytocinase (ng/mL) was significantly lower at T 0 (1.41 [0.67, 3.51] vs. 0.40 [0.29, 1.12]; p = 0.03) in the obese group. Conclusion We provide preliminary evidence that the disposition of OXT may not be different between obese and nonobese women during labor.

Original languageEnglish
Pages (from-to)E177-E184
JournalAJP Reports
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2019

Keywords

  • augmentation of labor
  • induction of labor
  • obesity
  • oxytocin
  • oxytocinase
  • pregnancy

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