Oxysterols as non-genomic regulators of cholesterol homeostasis

Agata A. Bielska; Paul Schlesinger; Douglas F. Covey; Daniel S. Ory

doi:10.1016/j.tem.2011.12.002

Oxysterols as non-genomic regulators of cholesterol homeostasis

Agata A. Bielska, Paul Schlesinger, Douglas F. Covey, Daniel S. Ory

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states.

Original language	English
Pages (from-to)	99-106
Number of pages	8
Journal	Trends in Endocrinology and Metabolism
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.tem.2011.12.002
State	Published - Mar 2012

Access to Document

10.1016/j.tem.2011.12.002

Cite this

@article{018d0ef814af4b91b931790b71032ba6,

title = "Oxysterols as non-genomic regulators of cholesterol homeostasis",

abstract = "Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states.",

author = "Bielska, {Agata A.} and Paul Schlesinger and Covey, {Douglas F.} and Ory, {Daniel S.}",

note = "Funding Information: This work was supported by National Institutes of Health grants HL067773 (D.S.O.), HL097563 (A.A.B.) and T32 HL07275 (A.A.B.).",

year = "2012",

month = mar,

doi = "10.1016/j.tem.2011.12.002",

language = "English",

volume = "23",

pages = "99--106",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

number = "3",

}

TY - JOUR

T1 - Oxysterols as non-genomic regulators of cholesterol homeostasis

AU - Bielska, Agata A.

AU - Schlesinger, Paul

AU - Covey, Douglas F.

AU - Ory, Daniel S.

N1 - Funding Information: This work was supported by National Institutes of Health grants HL067773 (D.S.O.), HL097563 (A.A.B.) and T32 HL07275 (A.A.B.).

PY - 2012/3

Y1 - 2012/3

N2 - Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states.

AB - Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states.

UR - http://www.scopus.com/inward/record.url?scp=84857686547&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2011.12.002

DO - 10.1016/j.tem.2011.12.002

M3 - Article

C2 - 22244444

AN - SCOPUS:84857686547

SN - 1043-2760

VL - 23

SP - 99

EP - 106

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 3

ER -

Oxysterols as non-genomic regulators of cholesterol homeostasis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this