TY - JOUR
T1 - Overview of the First NRG Oncology-National Cancer Institute Workshop on Dosimetry of Systemic Radiopharmaceutical Therapy
AU - Roncali, Emilie
AU - Capala, Jacek
AU - Benedict, Stanley H.
AU - Akabani, Gamal
AU - Bednarz, Bryan
AU - Bhadrasain, Vikram
AU - Bolch, Wesley E.
AU - Buchsbaum, Jeffrey C.
AU - Coleman, Norman C.
AU - Dewaraja, Yuni K.
AU - Frey, Eric
AU - Ghaly, Michael
AU - Grudzinski, Joseph
AU - Hobbs, Robert F.
AU - Howell, Roger W.
AU - Humm, John L.
AU - Kunos, Charles A.
AU - Larson, Steve
AU - Lin, Frank I.
AU - Madsen, Mark
AU - Mirzadeh, Saed
AU - Morse, David
AU - Pryma, Daniel
AU - Sgouros, George
AU - St. James, Sara
AU - Wahl, Richard L.
AU - Xiao, Ying
AU - Zanzonico, Pat
AU - Zukotynski, Katherine
N1 - Publisher Copyright:
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - In 2018, the National Cancer Institute and NRG Oncology partnered for the first time to host a joint workshop on systemic radiopharmaceutical therapy (RPT) to specifically address dosimetry issues and strategies for future clinical trials. The workshop focused on current dosimetric approaches for clinical trials, strategies under development that would optimize dose reporting, and future desired or optimized approaches for novel emerging radionuclides and carriers in development. In this article, we review the main approaches that are applied clinically to calculate the absorbed dose. These include absorbed doses calculated over a variety of spatial scales, including whole body, organ, suborgan, and voxel, the last 3 of which are achievable within the MIRD schema (S value) and can be calculated with analytic methods or Monte Carlo methods, the latter in most circumstances. This article will also contrast currently available methods and tools with those used in the past, to propose a pathway whereby dosimetry helps the field by optimizing the biologic effect of the treatment and trial design in the drug approval process to reduce financial and logistical costs. We also briefly discuss the dosimetric equivalent of biomarkers to help bring a precision medicine approach to RPT implementation when merited by evidence collected during early-phase trial investigations. Advances in the methodology and related tools have made dosimetry the optimum biomarker for RPT.
AB - In 2018, the National Cancer Institute and NRG Oncology partnered for the first time to host a joint workshop on systemic radiopharmaceutical therapy (RPT) to specifically address dosimetry issues and strategies for future clinical trials. The workshop focused on current dosimetric approaches for clinical trials, strategies under development that would optimize dose reporting, and future desired or optimized approaches for novel emerging radionuclides and carriers in development. In this article, we review the main approaches that are applied clinically to calculate the absorbed dose. These include absorbed doses calculated over a variety of spatial scales, including whole body, organ, suborgan, and voxel, the last 3 of which are achievable within the MIRD schema (S value) and can be calculated with analytic methods or Monte Carlo methods, the latter in most circumstances. This article will also contrast currently available methods and tools with those used in the past, to propose a pathway whereby dosimetry helps the field by optimizing the biologic effect of the treatment and trial design in the drug approval process to reduce financial and logistical costs. We also briefly discuss the dosimetric equivalent of biomarkers to help bring a precision medicine approach to RPT implementation when merited by evidence collected during early-phase trial investigations. Advances in the methodology and related tools have made dosimetry the optimum biomarker for RPT.
KW - MIRD
KW - cellular dosimetry
KW - dosimetry
KW - microdosimetry
KW - radiopharmaceutical therapy (RPT)
KW - targeted radionuclide therapy (TRT)
UR - http://www.scopus.com/inward/record.url?scp=85112245218&partnerID=8YFLogxK
U2 - 10.2967/JNUMED.120.255547
DO - 10.2967/JNUMED.120.255547
M3 - Article
C2 - 33277396
AN - SCOPUS:85112245218
SN - 0161-5505
VL - 62
SP - 1133
EP - 1139
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 8
ER -