Overview of severe clostridium difficile infection

Stephen R. Eaton, John E. Mazuski

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Clostridium difficile is an anaerobic, spore-forming, gram-positive bacillus that can produce severe colitis resulting in death. There has been an overall increase in the incidence of Clostridium difficile-associated disease and, particularly, an increase in the more virulent forms of the disease. Treatment of severe C difficile infection includes management of severe sepsis and shock, pathogen-directed antibiotic therapy, and, in selected cases, surgical intervention. Ultimately, prevention is the key to limiting the devastating effects of this microorganism.

Original languageEnglish
Pages (from-to)827-839
Number of pages13
JournalCritical Care Clinics
Issue number4
StatePublished - Oct 2013


  • Clostridium difficile
  • Clostridium difficile colitis
  • Nosocomial infection
  • Pseudomembranous colitis


Dive into the research topics of 'Overview of severe clostridium difficile infection'. Together they form a unique fingerprint.

Cite this