Overview of Histopathology of Ulcerative Colitis and Crohn's Disease

Michael D. Chang, Xiuli Liu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Macroscopic and microscopic examinations of intestinal biopsies or resection specimens play an essential role in diagnosing and managing patients with inflammatory bowel disease (IBD). This chapter discusses the histopathology of typical ulcerative colitis (UC) and Crohn's disease (CD), some unusual features or variants of UC and CD, and indeterminate colitis. In addition, it details the histomorphologic criteria for diagnosing and grading dysplasia and colorectal cancer arising from IBD, particularly some recently described, diagnostically challenging variants. Furthermore, it discusses the most recent advances in the interpretation of IBD-associated neoplasia in the context of the SCENIC international consensus statement on surveillance and management of dysplasia in IBD. Pathology of the ileal pouch is also discussed.

Original languageEnglish
Title of host publicationInterventional Inflammatory Bowel Disease
Subtitle of host publicationEndoscopic Management and Treatment of Complications
Number of pages20
ISBN (Electronic)9780128113882
ISBN (Print)9780128113899
StatePublished - Jan 1 2018


  • Colorectal cancer
  • Crohn's disease
  • Dysplasia
  • Ileal pouch-anal anastomosis
  • Indeterminate colitis
  • Inflammatory bowel disease
  • Ulcerative colitis


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