Overview of Histopathology of Ulcerative Colitis and Crohn's Disease

Michael D. Chang; Xiuli Liu

doi:10.1016/B978-0-12-811388-2.00005-1

Overview of Histopathology of Ulcerative Colitis and Crohn's Disease

Michael D. Chang, Xiuli Liu

Division of Anatomic and Molecular Pathology (AMP)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Macroscopic and microscopic examinations of intestinal biopsies or resection specimens play an essential role in diagnosing and managing patients with inflammatory bowel disease (IBD). This chapter discusses the histopathology of typical ulcerative colitis (UC) and Crohn's disease (CD), some unusual features or variants of UC and CD, and indeterminate colitis. In addition, it details the histomorphologic criteria for diagnosing and grading dysplasia and colorectal cancer arising from IBD, particularly some recently described, diagnostically challenging variants. Furthermore, it discusses the most recent advances in the interpretation of IBD-associated neoplasia in the context of the SCENIC international consensus statement on surveillance and management of dysplasia in IBD. Pathology of the ileal pouch is also discussed.

Original language	English
Title of host publication	Interventional Inflammatory Bowel Disease
Subtitle of host publication	Endoscopic Management and Treatment of Complications
Publisher	Elsevier
Pages	49-68
Number of pages	20
ISBN (Electronic)	9780128113882
ISBN (Print)	9780128113899
DOIs	https://doi.org/10.1016/B978-0-12-811388-2.00005-1
State	Published - Jan 1 2018

Keywords

Colorectal cancer
Crohn's disease
Dysplasia
Ileal pouch-anal anastomosis
Indeterminate colitis
Inflammatory bowel disease
Ulcerative colitis

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10.1016/B978-0-12-811388-2.00005-1

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title = "Overview of Histopathology of Ulcerative Colitis and Crohn's Disease",

abstract = "Macroscopic and microscopic examinations of intestinal biopsies or resection specimens play an essential role in diagnosing and managing patients with inflammatory bowel disease (IBD). This chapter discusses the histopathology of typical ulcerative colitis (UC) and Crohn's disease (CD), some unusual features or variants of UC and CD, and indeterminate colitis. In addition, it details the histomorphologic criteria for diagnosing and grading dysplasia and colorectal cancer arising from IBD, particularly some recently described, diagnostically challenging variants. Furthermore, it discusses the most recent advances in the interpretation of IBD-associated neoplasia in the context of the SCENIC international consensus statement on surveillance and management of dysplasia in IBD. Pathology of the ileal pouch is also discussed.",

keywords = "Colorectal cancer, Crohn's disease, Dysplasia, Ileal pouch-anal anastomosis, Indeterminate colitis, Inflammatory bowel disease, Ulcerative colitis",

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AB - Macroscopic and microscopic examinations of intestinal biopsies or resection specimens play an essential role in diagnosing and managing patients with inflammatory bowel disease (IBD). This chapter discusses the histopathology of typical ulcerative colitis (UC) and Crohn's disease (CD), some unusual features or variants of UC and CD, and indeterminate colitis. In addition, it details the histomorphologic criteria for diagnosing and grading dysplasia and colorectal cancer arising from IBD, particularly some recently described, diagnostically challenging variants. Furthermore, it discusses the most recent advances in the interpretation of IBD-associated neoplasia in the context of the SCENIC international consensus statement on surveillance and management of dysplasia in IBD. Pathology of the ileal pouch is also discussed.

KW - Colorectal cancer

KW - Crohn's disease

KW - Dysplasia

KW - Ileal pouch-anal anastomosis

KW - Indeterminate colitis

KW - Inflammatory bowel disease

KW - Ulcerative colitis

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BT - Interventional Inflammatory Bowel Disease

PB - Elsevier

ER -

Overview of Histopathology of Ulcerative Colitis and Crohn's Disease

Abstract

Keywords

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