Overview of C3 glomerulopathy

Vimal Master Sankar Raj, Roberto Gordillo, Deepa H. Chand

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.

Original languageEnglish
Article number45
JournalFrontiers in Pediatrics
Issue numberMAY
StatePublished - May 1 2016


  • Atypical HUS
  • C3 glomerulopathies
  • Children
  • Complement C3
  • Kidney disease


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