Overview of C3 glomerulopathy

Vimal Master Sankar Raj; Roberto Gordillo; Deepa H. Chand

doi:10.3389/fped.2016.00045

Overview of C3 glomerulopathy

Vimal Master Sankar Raj, Roberto Gordillo, Deepa H. Chand

Division of Nephrology, Hypertension & Apheresis

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.

Original language	English
Article number	45
Journal	Frontiers in Pediatrics
Volume	4
Issue number	MAY
DOIs	https://doi.org/10.3389/fped.2016.00045
State	Published - May 1 2016

Keywords

Atypical HUS
C3 glomerulopathies
Children
Complement C3
Kidney disease

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10.3389/fped.2016.00045

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abstract = "C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.",

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AB - C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.

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Overview of C3 glomerulopathy

Abstract

Keywords

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