Abstract
A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.
Original language | English |
---|---|
Pages (from-to) | 161-164 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 202 |
Issue number | 3 |
DOIs | |
State | Published - Jan 5 1996 |
Keywords
- Bcl-2
- Differentiation
- Dopamine
- Mesencephalic cells
- Neurite extension