Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth

Young J. Oh, Barbara C. Swarzenski, Karen L. O'Malley

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/ Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/ Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Volume202
Issue number3
DOIs
StatePublished - Jan 5 1996

Keywords

  • Bcl-2
  • Differentiation
  • Dopamine
  • Mesencephalic cells
  • Neurite extension

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