Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer

Michael S. Kinch, Kelly Carles-Kinch

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations

Abstract

Cancer is a disease of aberrant signal transduction. The expression and function of intracellular signaling pathways are frequently subverted as cells progress towards a metastatic phenotype. In particular, tyrosine kinases initiate powerful signals that govern many different aspects of cell behavior. In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. Herein, we provide an overview of our current understanding of EphA2, with emphasis upon the differential regulation of EphA2 expression and function. We also show that differential EphA2 expression and function may provide a unique opportunity for selective therapeutic targeting of EphA2 in metastatic disease.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalClinical and Experimental Metastasis
Volume20
Issue number1
DOIs
StatePublished - 2003

Keywords

  • EphA2
  • Ephrin
  • Metastasis
  • Monoclonal antibody
  • Oncogene
  • Tyrosine kinase

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