TY - JOUR
T1 - Overcoming the funding challenge
T2 - The cost of randomized controlled trials in the next decade
AU - Shore, Benjamin J.
AU - Nasreddine, Adam Y.
AU - Kocher, Mininder S.
PY - 2012/7/18
Y1 - 2012/7/18
N2 - Randomized controlled trials (RCTs) represent the gold standard of evidence-based medicine. However, over the last several decades, the cost associated with conducting RCTs has increased dramatically. Several factors contribute to higher costs associated with clinical trials. This paper describes important barriers to conducting surgical RCTs, identifies funding sources available to finance RCTs, and suggests strategies to maintain cost-efficient study practices as we move into the next decade.
AB - Randomized controlled trials (RCTs) represent the gold standard of evidence-based medicine. However, over the last several decades, the cost associated with conducting RCTs has increased dramatically. Several factors contribute to higher costs associated with clinical trials. This paper describes important barriers to conducting surgical RCTs, identifies funding sources available to finance RCTs, and suggests strategies to maintain cost-efficient study practices as we move into the next decade.
UR - https://www.scopus.com/pages/publications/84866908603
U2 - 10.2106/JBJS.L.00193
DO - 10.2106/JBJS.L.00193
M3 - Review article
C2 - 22810458
AN - SCOPUS:84866908603
SN - 0021-9355
VL - 94
SP - 101
EP - 106
JO - Journal of Bone and Joint Surgery
JF - Journal of Bone and Joint Surgery
IS - SUPPL. 1
ER -