TY - JOUR
T1 - Ovarian Tissue Cryopreservation in Pediatric Centers across the United States
T2 - Practice Patterns and Barriers
AU - Kebodeaux, Chelsea A.
AU - Pruett, Megan
AU - Gomez-Lobo, Veronica
AU - Nahata, Leena
AU - Saraf, Amanda J.
AU - Hoefgen, Holly R.
N1 - Publisher Copyright:
© 2024
PY - 2024
Y1 - 2024
N2 - Study Objective: To evaluate practice patterns in ovarian tissue cryopreservation (OTC) provision Methods: US providers practicing or developing OTC in pediatric programs were invited to participate in a survey disseminated via the Oncofertility Consortium. Results: Twenty-seven programs representing a wide geographic area responded, largely representing academic institutions (85.2%). Of these, 21 (77.4%) performed OTC at their facility, most for oncology patients receiving gonadotoxic therapy, relapsed patients, and non-oncologic patients receiving gonadotoxic therapy (95.7%, 87.0%, and 82.6%, respectively). OTC procedures were most commonly performed by pediatric gynecology surgeons (71.4%) via laparoscopic oophorectomy (90.5%) using a heat-based method (55.0%) for dissection. Most centers used an outside compensated service (50%) or a reproductive endocrinology group (45%) for processing tissue. Many (13, 61.9%) performed OTC as standard of care, and 7 utilized an institutional review board for data collection. Of the 8 centers whose OTC programs were in the planning or early stages, frequently identified barriers were lack of priority within their medical team or institution (5/8), lack of protected time (3/8), and lack of funding (3/8). Conclusion: OTC is commonly offered to oncology patients receiving highly gonadotoxic therapy, with pediatric gynecologists frequently involved in counseling and performing OTC. Variability exists in offering OTC to other patient populations, as well as in research practices, surgical technique, and processing. Institutions continue to face barriers in offering OTC when necessary resources are not prioritized by leadership.
AB - Study Objective: To evaluate practice patterns in ovarian tissue cryopreservation (OTC) provision Methods: US providers practicing or developing OTC in pediatric programs were invited to participate in a survey disseminated via the Oncofertility Consortium. Results: Twenty-seven programs representing a wide geographic area responded, largely representing academic institutions (85.2%). Of these, 21 (77.4%) performed OTC at their facility, most for oncology patients receiving gonadotoxic therapy, relapsed patients, and non-oncologic patients receiving gonadotoxic therapy (95.7%, 87.0%, and 82.6%, respectively). OTC procedures were most commonly performed by pediatric gynecology surgeons (71.4%) via laparoscopic oophorectomy (90.5%) using a heat-based method (55.0%) for dissection. Most centers used an outside compensated service (50%) or a reproductive endocrinology group (45%) for processing tissue. Many (13, 61.9%) performed OTC as standard of care, and 7 utilized an institutional review board for data collection. Of the 8 centers whose OTC programs were in the planning or early stages, frequently identified barriers were lack of priority within their medical team or institution (5/8), lack of protected time (3/8), and lack of funding (3/8). Conclusion: OTC is commonly offered to oncology patients receiving highly gonadotoxic therapy, with pediatric gynecologists frequently involved in counseling and performing OTC. Variability exists in offering OTC to other patient populations, as well as in research practices, surgical technique, and processing. Institutions continue to face barriers in offering OTC when necessary resources are not prioritized by leadership.
KW - Barriers
KW - Fertility preservation
KW - Oncofertility
KW - Ovarian tissue cryopreservation (OTC)
KW - Practice patterns
UR - http://www.scopus.com/inward/record.url?scp=85212387550&partnerID=8YFLogxK
U2 - 10.1016/j.jpag.2024.11.002
DO - 10.1016/j.jpag.2024.11.002
M3 - Article
C2 - 39557187
AN - SCOPUS:85212387550
SN - 1083-3188
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
ER -