Outcomes of Severely Obese Patients Supported by a Centrifugal-Flow Left Ventricular Assist Device: Outcomes of HVAD Patients With Severe Obesity

Michael S. Kiernan, Samer S. Najjar, Amanda R. Vest, Emma J. Birks, Nir Uriel, Gregory A. Ewald, Katrin Leadley, Chetan B. Patel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Ventricular assist devices provide improved outcomes for patients with advanced heart failure, but their benefit in the severely obese is not well documented. Methods: Patients enrolled in the HeartWare ADVANCE trial (n=382) were divided into 2 body mass index (BMI) groups. Patients with severe obesity (>35 kg/m2) were compared with a control group with BMI ≤35 kg/m2. The association of BMI with survival was tested using Kaplan–Meier analysis and major adverse events were compared. Results: At implantation, 48 (13%) of patients were severely obese. There was no difference in survival through 2 years of support between severely obese patients and the control group. Severely obese patients were at higher risk of driveline infection (P = .01) and acute renal dysfunction (P = .002). Both groups experienced similar improvements in quality of life. Functional capacity improved in both severely obese and control patients, although severely obese patients had smaller improvements than controls in their 6-minute walk scores. Conclusions: Despite an increased risk of adverse events, severe obesity was not associated with reduced survival or quality of life. A better understanding of the risks and benefits of left ventricular assist device therapy in obese patients will help in the shared decision-making of the patient selection process.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalJournal of cardiac failure
Volume26
Issue number2
DOIs
StatePublished - Feb 2020

Keywords

  • Left ventricular assist device
  • obesity
  • patient outcomes

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